TABLE OF CONTENTS
Volume 20, Issue 1 (January 2006)
Spotlight
Inhibition of human leukemia xenograft in nude mice by adenovirus-mediated tissue inhibitor of metalloproteinase-3
X F Yu, C Yang, L H Liang, B Liu, B Zhou, B Li and Z C Han
Leukemia 20: 1-8; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2404021
Meeting Report
The eighth international childhood acute lymphoblastic leukemia workshop ('Ponte di Legno meeting') report: Vienna, Austria, April 27–28, 2005
H Gadner, G Masera, M Schrappe, T Eden, Y Benoit, C Harrison, J Nachman and C-H Pui
Leukemia 20: 9-17; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2404016
Original Articles
New Directions in Stem Cell Research
Cells enriched in markers of neural tissue-committed stem cells reside in the bone marrow and are mobilized into the peripheral blood following stroke
M Kucia, Y P Zhang, R Reca, M Wysoczynski, B Machalinski, M Majka, S T Ildstad, J Ratajczak, C B Shields and M Z Ratajczak
Leukemia 20: 18-28; advance online publication, November 3, 2005; doi:10.1038/sj.leu.2404011
Acute Non-Lymphocytic Leukemias
Absolute lymphocyte count recovery after induction chemotherapy predicts superior survival in acute myelogenous leukemia
D Behl, L F Porrata, S N Markovic, L Letendre, R K Pruthi, C C Hook, A Tefferi, M A Elliot, S H Kaufmann, R A Mesa and M R Litzow
Leukemia 20: 29-34; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2404032
Extramedullary relapse in acute promyelocytic leukemia treated with all-trans retinoic acid and chemotherapy
S de Botton, M A Sanz, S Chevret, H Dombret, G Martin, X Thomas, J D Mediavilla, C Recher, L Ades, B Quesnel, P Brault, M Fey, H Wandt, D Machover, A Guerci, F Maloisel, A M Stoppa, C Rayon, J M Ribera, C Chomienne, L Degos and P Fenaux
Leukemia 20: 35-41; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404006
Attitude towards remission induction for elderly patients with acute myeloid leukemia influences survival
G Juliusson, R Billström, A Gruber, E Hellström-Lindberg, M Höglund, K Karlsson, D Stockelberg, A Wahlin, M Åström, C Arnesson, U Brunell-Abrahamsson, J Carstensen, E Fredriksson, E Holmberg, K Nordenskjöld and F Wiklund for the Swedish Adult Acute Leukemia Registry Group
Leukemia 20: 42-47; advance online publication, November 21, 2005; doi:10.1038/sj.leu.2404004
Characterization of a recurrent translocation t(2;3)(p15–22;q26) occurring in acute myeloid leukaemia
M Trubia, F Albano, F Cavazzini, G R Cambrin, G Quarta, F Fabbiano, F Ciambelli, D Magro, J M Hernandez, M Mancini, D Diverio, P G Pelicci, F L Coco, C Mecucci, G Specchia, M Rocchi, V Liso, G Castoldi and A Cuneo
Leukemia 20: 48-54; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404020
Chronic Myeloid Leukemia, BCR/ABL Studies and Myeloproliferative Disorders
Frequency and risk factors for thrombosis in idiopathic myelofibrosis: analysis in a series of 155 patients from a single institution
F Cervantes, A Alvarez-Larrán, E Arellano-Rodrigo, M Granell, A Domingo and E Montserrat
Leukemia 20: 55-60; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404048
The NF-
B pathway blockade by the IKK inhibitor PS1145 can overcome Imatinib resistance
D Cilloni, F Messa, F Arruga, I Defilippi, A Morotti, E Messa, S Carturan, E Giugliano, M Pautasso, E Bracco, V Rosso, A Sen, G Martinelli, M Baccarani and G Saglio
Leukemia 20: 61-67; advance online publication, November 3, 2005; doi:10.1038/sj.leu.2403998
Transient or long-term silencing of BCR-ABL alone induces cell cycle and proliferation arrest, apoptosis and differentiation
J Rangatia and D Bonnet
Leukemia 20: 68-76; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2403999
CLL
The G(-248)A polymorphism in the promoter region of the Bax gene does not correlate with prognostic markers or overall survival in chronic lymphocytic leukemia
Å Skogsberg, G Tobin, A Kröber, D Kienle, U Thunberg, A Åleskog, K Karlsson, A Laurell, M Merup, J Vilpo, C Sundström, G Roos, H Jernberg-Wiklund, H Döhner, K Nilsson, S Stilgenbauer and R Rosenquist
Leukemia 20: 77-81; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404030
T-Leukemias
Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias
E Clappier, W Cuccuini, J-M Cayuela, D Vecchione, A Baruchel, H Dombret, F Sigaux and J Soulier
Leukemia 20: 82-86; advance online publication, November 3, 2005; doi:10.1038/sj.leu.2404008
Minimal Residual Disease in AML
Prognostic value of minimal residual disease (MRD) in acute myeloid leukemia (AML) with favorable cytogenetics [t(8;21) and inv(16)]
G Perea, A Lasa, A Aventín, A Domingo, N Villamor, M Paz Queipo de Llano, A Llorente, J Juncà, C Palacios, C Fernández, M Gallart, L Font, M Tormo, L Florensa, J Bargay, J M Martí, P Vivancos, P Torres, J J Berlanga, I Badell, S Brunet, J Sierra and J F Nomdedéu for the Grupo Cooperativo para el Estudio y Tratamiento de las Leucemias Agudas y Mielodisplasias (CETLAM). Spain
Leukemia 20: 87-94; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2404015
Sensitivity and Resistance to Leukemia
Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting shingosine kinase-1
E Bonhoure, D Pchejetski, N Aouali, H Morjani, T Levade, T Kohama and O Cuvillier
Leukemia 20: 95-102; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2404023
Gene Expression Profiles and Microarrays
Gene expression profiling of acute promyelocytic leukaemia identifies two subtypes mainly associated with Flt3 mutational status
R Marasca, R Maffei, P Zucchini, I Castelli, A Saviola, S Martinelli, A Ferrari, M Fontana, S Ravanetti and G Torelli
Leukemia 20: 103-114; advance online publication, November 3, 2005; doi:10.1038/sj.leu.2404000
Differentiation
Effects of 5-aza-2'-deoxycytidine on proliferation, differentiation and p15/INK4b regulation of human hematopoietic progenitor cells
Y Guo, M Engelhardt, D Wider, M Abdelkarim and M Lübbert
Leukemia 20: 115-121; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404019
Fatty acids, inhibitors for the DNA binding of c-Myc/Max dimer, suppress proliferation and induce apoptosis of differentiated HL-60 human leukemia cell
K C Jung, C H Park, Y H Hwang, H S Rhee, J H Lee, H-K Kim and C H Yang
Leukemia 20: 122-127; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2404022
Stem Cell Transplantation
Myeloablative vs nonmyeloablative allogeneic transplantation for patients with myelodysplastic syndrome or acute myelogenous leukemia with multilineage dysplasia: a retrospective analysis
B L Scott, B M Sandmaier, B Storer, M B Maris, M L Sorror, D G Maloney, T R Chauncey, R Storb and H J Deeg
Leukemia 20: 128-135; advance online publication, November 3, 2005; doi:10.1038/sj.leu.2404010
Follow-up on Children with Acute Myeloid Leukemia
Improved treatment results for childhood acute myeloid leukemia in Taiwan
D-C Liang, T-T Chang, K-H Lin, D-T Lin, M-Y Lu, S-H Chen, H-C Liu, M-T Lin, M-T Lee, S-G Shu, T-K Chang, J-S Chen, C-C Hsiao, I-J Hung, Y-L Hsieh, R-L Chen, S-N Cheng, W-H Chang, C-H Lee and K-S Lin
Leukemia 20: 136-141; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2403979
Original Articles
Spotlight Letter to the Editor
Imatinib does not impair specific antitumor T-cell immunity in patients with chronic myeloid leukemia
M Bocchia, E Abruzzese, F Forconi, M Ippoliti, M M Trawinska, M T Pirrotta, D Raspadori, M Tozzi, A Gozzetti and F Lauria
Leukemia 20: 142-143; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2404029
The role of P-glycoporotein in imatinib resistance
H Rumpold, A-M Wolf and D Wolf
Leukemia 20: 144; advance online publication, November 3, 2005; doi:10.1038/sj.leu.2404001
Reply to Rumpold et al
Y Zong, S Zhou and B P Sorrentino
Leukemia 20: 144-145; advance online publication, November 3, 2005; doi:10.1038/sj.leu.2404002
hRap1B-retro: a novel human processed Rap1B gene blurs the picture?
T Zemojtel, T Penzkofer, M Duchniewicz and F J T Zwartkruis
Leukemia 20: 145-146; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404040
Reply to 'hRap1B-retro: a novel human processed Rap1B gene blurs the picture?' by Zemojtel et al
E Gyan, F Porteu and M Fontenay
Leukemia 20: 146-147; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404042
Epidemiological analysis of second primary malignancies in more than 9500 patients treated with imatinib
P R Pilot, K Sablinska, S Owen and A Hatfield
Leukemia 20: 148; advance online publication, November 17, 2005; doi:10.1038/sj.leu.2404025
Reply to 'Epidemiological analysis of second primary malignancies in more than 9500 patients treated with imatinib' by Pilot et al.
L Roy, J Guilhot, G Martineau and F Guilhot
Leukemia 20: 149; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2404027
CDKN2B methylation is an independent poor prognostic factor in newly diagnosed acute promyelocytic leukemia
C-S Chim, J S Lau, K-F Wong and Y-L Kwong
Leukemia 20: 149-151; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404052
Nf1 gene inactivation in acute myeloid leukemia cells confers cytarabine resistance through MAPK and mTOR pathways
B Yin, K Morgan, D E Hasz, Z Mao and D A Largaespada
Leukemia 20: 151-154; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404033
Maintained immunogenicity of chronic myeloid leukemia-derived dendritic cells in the presence of Imatinib mesylate: implication for vaccination regimens
T M Westers, J J W M Janssen, I Houtenbos, N C L Snoijs, A A van de Loosdrecht and G J Ossenkoppele
Leukemia 20: 154-157; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404043
Absence of the JAK2 V617F activating mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma
I Melzner, M A Weniger, C K Menz and P Möller
Leukemia 20: 157-158; advance online publication, December 3, 2005; doi:10.1038/sj.leu.2404036
Long-term clonal persistence and evolution of t(14;18)-bearing B cells in healthy individuals
S Roulland, P Lebailly, Y Lecluse, N Heutte, B Nadel and P Gauduchon
Leukemia 20: 158-162; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404035
Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2
B Yatsula, C Galvao, M McCrann and A S Perkins
Leukemia 20: 162-165; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404034
Expression of Tel-Aml1 transcript variants in pediatric acute lymphoblastic leukemia
A M Kustanovich, M V Belevtsev, I V Stasevich, T V Savitskaya, R I Jutzkevich, N N Savva and O V Aleinikova
Leukemia 20: 165-167; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404028
Major molecular response to imatinib in a patient with chronic myeloid leukemia expressing a novel form of e8a2 BCR-ABL transcript
A Tchirkov, J-L Couderc, B Périssel, C Goumy, A Regnier, N Uhrhammer, P Verrelle and M Berger
Leukemia 20: 167-168; advance online publication, November 3, 2005; doi:10.1038/sj.leu.2404012
Validation of two clinically useful assays for evaluation of JAK2 V617F mutation in chronic myeloproliferative disorders
R McClure, M Mai and T Lasho
Leukemia 20: 168-171; advance online publication, November 3, 2005; doi:10.1038/sj.leu.2404007
Rituximab is effective for steroid-refractory sclerodermatous chronic graft-versus-host disease
M Okamoto, A Okano, S Akamatsu, E Ashihara, T Inaba, H Takenaka, N Katoh, S Kishimoto and C Shimazaki
Leukemia 20: 172-173; advance online publication, October 20, 2005; doi:10.1038/sj.leu.2403996
IGF-1R is overexpressed in poor-prognostic subtypes of multiple myeloma
W J Chng, A Gualberto and R Fonseca
Leukemia 20: 174-176; advance online publication, October 20, 2005; doi:10.1038/sj.leu.2403997
Validation of immunoglobulin gene rearrangement detection by PCR using commercially available BIOMED-2 primers
R F McClure, P Kaur, E Pagel, P D Ouillette, C E Holtegaard, C L Treptow and P J Kurtin
Leukemia 20: 176-179; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404049
MLL gene rearrangements have no direct impact on Ara-C sensitivity in infant acute lymphoblastic leukemia and childhood M4/M5 acute myeloid leukemia
R W Stam, I Hubeek, M L den Boer, J G C A M Buijs-Gladdines, U Creutzig, G J L Kaspers and R Pieters
Leukemia 20: 179-182; advance online publication, November 24, 2005; doi:10.1038/sj.leu.2404031
