TABLE OF CONTENTS
Volume 19, Issue 8 (August 2005)
Spotlight on Acute Promyelocytic Leukemia |
Review |
Keynote Address |
Commentaries |
Original Manuscripts |
Biotechnical Methods Section |
Spotlight Correspondence |
Correspondence
Leading Article
FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations
I Wlodarska, E Veyt, P De Paepe, P Vandenberghe, P Nooijen, I Theate, L Michaux, X Sagaert, P Marynen, A Hagemeijer and C De Wolf-Peeters
Leukemia 19: 1299-1305; advance online publication, June 9, 2005; doi:10.1038/sj.leu.2403813
Spotlight on Acute Promyelocytic Leukemia
Efficacy of gemtuzumab ozogamicin on ATRA- and arsenic-resistant acute promyelocytic leukemia (APL) cells
A Takeshita, K Shinjo, K Naito, H Matsui, N Sahara, K Shigeno, T Horii, N Shirai, M Maekawa, K Ohnishi, T Naoe and R Ohno
Leukemia 19: 1306-1311; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403807
Antiangiogenic treatment with endostatin inhibits progression of AML in vivo
G Schuch, L Oliveira-Ferrer, S Loges, E Laack, C Bokemeyer, D K Hossfeld, W Fiedler and S Ergun
Leukemia 19: 1312-1317; advance online publication, June 2, 2005; doi:10.1038/sj.leu.2403824
Review
Wilms' tumour gene 1 (WT1) in human neoplasia
U Keilholz, H D Menssen, A Gaiger, A Menke, Y Oji, Y Oka, C Scheibenbogen, H Stauss, E Thiel and H Sugiyama
Leukemia 19: 1318-1323; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403817
Keynote Address
Is there a role for postremission therapy in older adults with acute myelogenous leukemia (AML)?
J M Rowe
Leukemia 19: 1324-1327; advance online publication, June 9, 2005; doi:10.1038/sj.leu.2403827
Commentaries
HOX genes: not just myeloid oncogenes any more
H J Lawrence, N A Fischbach and C Largman
Leukemia 19: 1328-1330; advance online publication, June 2, 2005; doi:10.1038/sj.leu.2403816
Higher-grade transformation of follicular lymphoma – a continuous enigma
I S Lossos
Leukemia 19: 1331-1333; advance online publication, May 19, 2005; doi:10.1038/sj.leu.2403801
Intrahospital supervised exercise training: a complementary tool in the therapeutic armamentarium against childhood leukemia
A Lucia, M Ramírez, A F San Juan, S J Fleck, J García-Castro and L Madero
Leukemia 19: 1334-1337; advance online publication, June 2, 2005; doi:10.1038/sj.leu.2403799
Original Manuscripts
Acute Non-Lymphocytic Leukemias
DEK-CAN molecular monitoring of myeloid malignancies could aid therapeutic stratification
L Garçon, M Libura, E Delabesse, F Valensi, V Asnafi, C Berger, C Schmitt, T Leblanc, A Buzyn and E Macintyre
Leukemia 19: 1338-1344; advance online publication, June 23, 2005; doi:10.1038/sj.leu.2403835
Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis
M Yanada, K Matsuo, T Suzuki, H Kiyoi and T Naoe
Leukemia 19: 1345-1349; advance online publication, June 16, 2005; doi:10.1038/sj.leu.2403838
The novel triterpenoid CDDO-Me suppresses MAPK pathways and promotes p38 activation in acute myeloid leukemia cells
M Konopleva, R Contractor, S M Kurinna, W Chen, M Andreeff and P P Ruvolo
Leukemia 19: 1350-1354; advance online publication, June 2, 2005; doi:10.1038/sj.leu.2403828
AML patients with Down syndrome have a high cure rate with AML-BFM therapy with reduced dose intensity
U Creutzig, D Reinhardt, S Diekamp, M Dworzak, J Stary and M Zimmermann
Leukemia 19: 1355-1360; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403814
Mutations in the receptor tyrosine kinase pathway are associated with clinical outcome in patients with acute myeloblastic leukemia harboring t(8;21)(q22;q22)
T Nanri, N Matsuno, T Kawakita, H Suzushima, F Kawano, H Mitsuya and N Asou
Leukemia 19: 1361-1366; advance online publication, May 19, 2005; doi:10.1038/sj.leu.2403803
Expression and methylation status of the FHIT gene in acute myeloid leukemia and myelodysplastic syndrome
M Iwai, H Kiyoi, K Ozeki, T Kinoshita, N Emi, R Ohno and T Naoe
Leukemia 19: 1367-1375; advance online publication, May 19, 2005; doi:10.1038/sj.leu.2403805
Chronic Lymphocytic Leukemia and Normal Lymphoid Cells
Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation
S Barrena, J Almeida, M Yunta, A López, N Fernández-Mosteirín, M Giralt, M Romero, L Perdiguer, M Delgado, A Orfao and P A Lazo
Leukemia 19: 1376-1383; advance online publication, June 2, 2005; doi:10.1038/sj.leu.2403822
T-Cell Leukemia
Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/
2-microglobulinnull mice
N Kawano, F Ishikawa, K Shimoda, M Yasukawa, K Nagafuji, T Miyamoto, E Baba, T Tanaka, S Yamasaki, H Gondo, T Otsuka, K Ohshima, L D Shultz, K Akashi and M Harada
Leukemia 19: 1384-1390; advance online publication, June 16, 2005; doi:10.1038/sj.leu.2403829
Acute Lymphocytic Leukemia
Molecular heterogeneity of sporadic adult Burkitt-type leukemia/lymphoma as revealed by PCR and cytogenetics: correlation with morphology, immunology and clinical features
T Burmeister, S Schwartz, H-A Horst, H Rieder, N Gökbuget, D Hoelzer and E Thiel
Leukemia 19: 1391-1398; advance online publication, June 23, 2005; doi:10.1038/sj.leu.2403847
Overt testicular disease at diagnosis of childhood acute lymphoblastic leukemia: lack of therapeutic role of local irradiation
N Hijiya, W Liu, J T Sandlund, S Jeha, B I Razzouk, R C Ribeiro, J E Rubnitz, S C Howard, E P Kyzer, D S Redd, C Cheng, G K Rivera, M M Hudson, M V Relling and C-H Pui
Leukemia 19: 1399-1403; advance online publication, June 23, 2005; doi:10.1038/sj.leu.2403843
Oncogenes
Dlk1 in normal and abnormal hematopoiesis
S Sakajiri, J O'Kelly, D Yin, C W Miller, W K Hofmann, K Oshimi, L-Y Shih, K-H Kim, H S Sul, C H Jensen, B Teisner, N Kawamata and H P Koeffler
Leukemia 19: 1404-1410; advance online publication, June 16, 2005; doi:10.1038/sj.leu.2403832
Cytogenetics
Common 4q24 deletion in four cases of hematopoietic malignancy: early stem cell involvement?
F Viguié, A Aboura, D Bouscary, S Ramond, A Delmer, G Tachdjian, J P Marie and N Casadevall
Leukemia 19: 1411-1415; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403818
Minimal Residual Disease
Prognostic impact of RT-PCR-based quantification of WT1 gene expression during MRD monitoring of acute myeloid leukemia
M Weisser, W Kern, S Rauhut, C Schoch, W Hiddemann, T Haferlach and S Schnittger
Leukemia 19: 1416-1423; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403809
Myelodysplasias
Incidence and prognostic significance of karyotype abnormalities in de novo primary myelodysplastic syndromes: a study on 331 patients from a single institution
P Bernasconi, C Klersy, M Boni, P M Cavigliano, S Calatroni, I Giardini, B Rocca, R Zappatore, M Caresana, J Quarna, M Lazzarino and C Bernasconi
Leukemia 19: 1424-1431; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403806
Immunology
Cell-based selection of internalizing fully human antagonistic antibodies directed against FLT3 for suppression of leukemia cell growth
B Williams, A Atkins, H Zhang, D Lu, X Jimenez, H Li, M-N Wang, D Ludwig, P Balderes, L Witte, Y Li and Z Zhu
Leukemia 19: 1432-1438; advance online publication, June 2, 2005; doi:10.1038/sj.leu.2403825
Differentiation
SET-induced calcium signaling and MAPK/ERK pathway activation mediate dendritic cell-like differentiation of U937 cells
A Kandilci and G C Grosveld
Leukemia 19: 1439-1445; advance online publication, June 2, 2005; doi:10.1038/sj.leu.2403826
Stem Cell Transplantation
A defined donor activating natural killer cell receptor genotype protects against leukemic relapse after related HLA-identical hematopoietic stem cell transplantation
S Verheyden, R Schots, W Duquet and C Demanet
Leukemia 19: 1446-1451; advance online publication, June 23, 2005; doi:10.1038/sj.leu.2403839
Lymphoma
Insights into the multistep transformation process of lymphomas: IgH-associated translocations and tumor suppressor gene mutations in clonally related composite Hodgkin's and non-Hodgkin's lymphomas
R Schmitz, C Renné, R Rosenquist, M Tinguely, V Distler, F Menestrina, M Lestani, T Stankovic, B Austen, A Bräuninger, M-L Hansmann and R Küppers
Leukemia 19: 1452-1458; advance online publication, June 23, 2005; doi:10.1038/sj.leu.2403841
A limited role for TP53 mutation in the transformation of follicular lymphoma to diffuse large B-cell lymphoma
A J Davies, A M Lee, C Taylor, A J Clear, L K Goff, S Iqbal, D Cuthbert-Heavens, M Calaminici, A J Norton, T A Lister and J Fitzgibbon
Leukemia 19: 1459-1465; advance online publication, May 19, 2005; doi:10.1038/sj.leu.2403802
Myeloma
CD45 expression by bone marrow plasma cells in multiple myeloma: clinical and biological correlations
S Kumar, S V Rajkumar, T Kimlinger, P R Greipp and T E Witzig
Leukemia 19: 1466-1470; advance online publication, June 16, 2005; doi:10.1038/sj.leu.2403823
Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferon-
(MIG) gene expression in B-cell malignancy
M Uranishi, S Iida, T Sanda, T Ishida, E Tajima, M Ito, H Komatsu, H Inagaki and R Ueda
Leukemia 19: 1471-1478; advance online publication, June 16, 2005; doi:10.1038/sj.leu.2403833
Biotechnical Methods Section
Simultaneous detection of NPM1 and FLT3-ITD mutations by capillary electrophoresis in acute myeloid leukemia
N I Noguera, E Ammatuna, D Zangrilli, S Lavorgna, M Divona, F Buccisano, S Amadori, C Mecucci, B Falini and F Lo-Coco
Leukemia 19: 1479-1482; advance online publication, June 23, 2005; doi:10.1038/sj.leu.2403846
Spotlight Correspondence
Gene expression profiling of normal hematopoietic progenitor cells under treatment with imatinib in vitro
S Balabanov, K Bartolovic, M Komor, L Kanz, W K Hofmann and T H Brümmendorf
Leukemia 19: 1483-1485; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403819
Correspondence
VEGF-induced survival of chronic lymphocytic leukemia is independent of Bcl-2 phosphorylation
L Wang, J E Coad, J M Fortney and L F Gibson
Leukemia 19: 1486-1487; advance online publication, June 16, 2005; doi:10.1038/sj.leu.2403837
Expression of BEX1 in acute myeloid leukemia with MLL rearrangements
H Quentmeier, R Tonelli, R Geffers, A Pession, C C Uphoff and H G Drexler
Leukemia 19: 1488-1489; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403820
Mutational status of IgVH genes in B-cell chronic lymphocytic leukemia and prognosis: percent mutations or antigen-driven selection?
R Bomben, M Dal Bo, A Zucchetto, E Zaina, P Nanni, P Sonego, G Del Poeta, M Degan and V Gattei
Leukemia 19: 1490-1492; advance online publication, June 9, 2005; doi:10.1038/sj.leu.2403830
RBM15 and MKL1 mutational screening in megakaryoblastic leukemia cell lines and clinical samples
H Kawaguchi, J K Hitzler, Z Ma and S W Morris
Leukemia 19: 1492-1494; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403812
Acute megakaryoblastic leukemia in children and adolescents, excluding Down's syndrome: improved outcome with intensified induction treatment
D Reinhardt, S Diekamp, C Langebrake, J Ritter, J Stary, M Dworzak, A Schrauder, M Zimmermann, G Fleischhack, W-D Ludwig, J Harbott and U Creutzig
Leukemia 19: 1495-1496; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403815
Long-term thalidomide therapy resulted in lack of mdr1 gene expression in a patient with primary resistant multiple myeloma
M Hus, A Dmoszyñska, J Kocki, I Hus, D Jawniak, M Adamczyk-Cioch and N Grzasko
Leukemia 19: 1497-1499; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403811
High expression of EDAG and its significance in AML
L-L An, G Li, K-F Wu, X-T Ma, G-G Zheng, L-G Qiu and Y-H Song
Leukemia 19: 1499-1502; advance online publication, May 26, 2005; doi:10.1038/sj.leu.2403808
Loss of Zap-70 and low molecular weight phosphotyrosine phosphatase occurs after therapy in a patient with B-chronic lymphocytic leukemia
Z Chen, E Aston and M K Yu
Leukemia 19: 1503-1505; advance online publication, June 2, 2005; doi:10.1038/sj.leu.2403793
Mesenchymal stem cells can be easily isolated from bone marrow of patients with various haematological malignancies but the surface antigens expression may be changed after prolonged ex vivo culture
S-P Yeh, J-G Chang, C-L Lin, W-J Lo, C-C Lee, C-Y Lin and C-F Chiu
Leukemia 19: 1505-1507; advance online publication, May 19, 2005; doi:10.1038/sj.leu.2403795
