TABLE OF CONTENTS
Volume 19, Issue 5 (May 2005)
Review
Animal models of acute myelogenous leukaemia – development, application and future perspectives
E Mc Cormack, Ø Bruserud and B T Gjertsen
Leukemia 19: 687-706; advance online publication, March 10, 2005; doi:10.1038/sj.leu.2403670
Commentaries
The CD107 mobilization assay: viable isolation and immunotherapeutic potential of tumor-cytolytic NK cells
M Uhrberg
Leukemia 19: 707-709; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403705
Regulation of glucocorticoid receptor steroid binding and trafficking by the hsp90/hsp70-based chaperone machinery: implications for clinical intervention
P J M Murphy
Leukemia 19: 710-712; advance online publication, March 10, 2005; doi:10.1038/sj.leu.2403687
Original Manuscripts
ALL
Genetic heterogeneity of BCR/ABL + adult B-cell precursor acute lymphoblastic leukemia: impact on the clinical, biological and immunophenotypical disease characteristics
D Primo, M D Tabernero, J J Perez, A Rasillo, J M Sayagués, A B Espinosa, M C Lopez-Berges, R García-Sanz, N C Gutierrez, J M Hernandez, M Romero, C S Osuna, M Giralt, M Barbon, J F San Miguel and A Orfao
Leukemia 19: 713-720; advance online publication, March 24, 2005; doi:10.1038/sj.leu.2403714
Value of intravenous 6-mercaptopurine during continuation treatment in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma: final results of a randomized phase III trial (58881) of the EORTC CLG
J van der Werff ten Bosch, S Suciu, A Thyss, Y Bertrand, L Norton, F Mazingue, A Uyttebroeck, P Lutz, A Robert, P Boutard, A Ferster, E Plouvier, P Maes, M Munzer, D Plantaz, M-F Dresse, P Philippet, N Sirvent, C Waterkeyn, E Vilmer, N Philippe and J Otten on behalf of the Children's Leukemia Group (CLG) of the European Organisation for Research and Treatment of Cancer (EORTC)
Leukemia 19: 721-726; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403689
mRNA expression levels of (co)chaperone molecules of the glucocorticoid receptor are not involved in glucocorticoid resistance in pediatric ALL
W J E Tissing, J P P Meijerink, M L den Boer, B Brinkhof and R Pieters
Leukemia 19: 727-733; advance online publication, March 10, 2005; doi:10.1038/sj.leu.2403681
High concordance from independent studies by the Children's Cancer Group (CCG) and Pediatric Oncology Group (POG) associating favorable prognosis with combined trisomies 4, 10, and 17 in children with NCI Standard-Risk B-precursor Acute Lymphoblastic Leukemia: a Children's Oncology Group (COG) initiative
M J Sutcliffe, J J Shuster, H N Sather, B M Camitta, J Pullen, K R Schultz, M J Borowitz, P S Gaynon, A J Carroll and N A Heerema
Leukemia 19: ; advance online publication, March 24, 2005; doi:10.1038/sj.leu.2403673
CLL
Analysis of V H gene sequences using two web-based immunogenetics resources gives different results, but the affinity maturation status of chronic lymphocytic leukaemia clones as assessed from either of the resulting data sets has no prognostic significance
B S Lane, A A Mensah, K Lin, A R Pettitt and P D Sherrington
Leukemia 19: 741-749; advance online publication, March 17, 2005; doi:10.1038/sj.leu.2403720
Combined analysis of ZAP-70 and CD38 expression as a predictor of disease progression in B-cell chronic lymphocytic leukemia
R Schroers, F Griesinger, L Trümper, D Haase, B Kulle, L Klein-Hitpass, L Sellmann, U Dührsen and J Dürig
Leukemia 19: 750-758; advance online publication, March 10, 2005; doi:10.1038/sj.leu.2403707
Good prognosis cytogenetics in B-cell chronic lymphocytic leukemia is associated in vitro with low susceptibility to apoptosis and enhanced immunogenicity
B Jahrsdörfer, J E Wooldridge, S E Blackwell, C M Taylor, B K Link and G J Weiner
Leukemia 19: 759-766; advance online publication, March 10, 2005; doi:10.1038/sj.leu.2403694
MDS
Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries
B Chen, W-L Zhao, J Jin, Y-Q Xue, X Cheng, X-T Chen, J Cui, Z-M Chen, Q Cao, G Yang, Y Yao, H-L Xia, J-H Tong, J-M Li, J Chen, S-M Xiong, Z-X Shen, S Waxman, Z Chen and S-J Chen
Leukemia 19: 767-775; advance online publication, March 10, 2005; doi:10.1038/sj.leu.2403688
Flow cytometry evaluation of erythroid and myeloid dysplasia in patients with myelodysplastic syndrome
L Malcovati, M G Della Porta, M Lunghi, C Pascutto, L Vanelli, E Travaglino, M Maffioli, P Bernasconi, M Lazzarino, R Invernizzi and M Cazzola
Leukemia 19: 776-783; advance online publication, March 24, 2005; doi:10.1038/sj.leu.2403680
Apoptosis
Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis
C Paquet, A-T Sané, M Beauchemin and R Bertrand
Leukemia 19: 784-791; advance online publication, March 10, 2005; doi:10.1038/sj.leu.2403717
CML
Molecular characterization of the idiopathic hypereosinophilic syndrome (HES) in 35 French patients with normal conventional cytogenetics
C Roche-Lestienne, S Lepers, V Soenen-Cornu, J-E Kahn, J-L Laï, E Hachulla, F Drupt, A-L Demarty, A-S Roumier, M Gardembas, M Dib, N Philippe, N Cambier, S Barete, C Libersa, O Bletry, P-Y Hatron, B Quesnel, C Rose, K Maloum, O Blanchet, P Fenaux, L Prin, C Preudhomme and and The French Eosinophil Network
Leukemia 19: 792-798; advance online publication, March 17, 2005; doi:10.1038/sj.leu.2403722
APL & Retinoid
ID1 and ID2 are retinoic acid responsive genes and induce a G0/G1 accumulation in acute promyelocytic leukemia cells
J Nigten, M C Breems-de Ridder, C A J Erpelinck-Verschueren, G Nikoloski, B A van der Reijden, S van Wageningen, P B van Hennik, T de Witte, B Löwenberg and J H Jansen
Leukemia 19: 799-805; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403699
Fusion Proteins
Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia
V Prima, L Gore, A Caires, T Boomer, M Yoshinari, M Imaizumi, M Varella-Garcia and S P Hunger
Leukemia 19: 806-813; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403684
Debate on Chimerism from Dr. Lion
Evaluation of immunomodulatory treatment based on conventional and lineage-specific chimerism analysis in patients with myeloid malignancies after myeloablative allogeneic hematopoietic cell transplantation
R Zeiser, A Spyridonidis, R Wäsch, G Ihorst, C Grüllich, H Bertz and J Finke
Leukemia 19: 814-821; advance online publication, March 17, 2005; doi:10.1038/sj.leu.2403719
Stem Cells
High doses of transplanted CD34+ cells are associated with rapid T-cell engraftment and lessened risk of graft rejection, but not more graft-versus-host disease after nonmyeloablative conditioning and unrelated hematopoietic cell transplantation
F Baron, M B Maris, B E Storer, B M Sandmaier, J P Panse, T R Chauncey, M Sorror, M-T Little, D G Maloney, R Storb and S Heimfeld
Leukemia 19: 822-828; advance online publication, March 17, 2005; doi:10.1038/sj.leu.2403718
Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphoma
T Fukushima, Y Miyazaki, S Honda, F Kawano, Y Moriuchi, M Masuda, R Tanosaki, A Utsunomiya, N Uike, S Yoshida, J Okamura and M Tomonaga
Leukemia 19: 829-834; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403682
Immunology
CD56dimCD16neg cells are responsible for natural cytotoxicity against tumor targets
O Penack, C Gentilini, L Fischer, A M Asemissen, C Scheibenbogen, E Thiel and L Uharek
Leukemia 19: ; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403704
Lymphoma
HLXB9 activates IL6 in Hodgkin lymphoma cell lines and is regulated by PI3K signalling involving E2F3
S Nagel, M Scherr, H Quentmeier, M Kaufmann, M Zaborski, H G Drexler and R A F MacLeod
Leukemia 19: ; advance online publication, March 17, 2005; doi:10.1038/sj.leu.2403716
Gadd45a acts as a modifier locus for lymphoblastic lymphoma
M C Hollander, A D Patterson, J M Salvador, M R Anver, S P Hunger and A J Fornace Jr
Leukemia 19: 847-850; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403711
High incidence of Kaposi sarcoma-associated herpesvirus infection in HIV-related solid immunoblastic/plasmablastic diffuse large B-cell lymphoma
S T P Deloose, L A Smit, F T Pals, M-J Kersten, C J M van Noesel and S T Pals
Leukemia 19: 851-855; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403709
Expression pattern of intracellular leukocyte-associated proteins in primary mediastinal B cell lymphoma
T Marafioti, M Pozzobon, M-L Hansmann, P Gaulard, T F Barth, C Copie-Bergman, H Roberton, R Ventura, J I Martín-Subero, R D Gascoyne, S A Pileri, R Siebert, E D Hsi, Y Natkunam, P Möller and D Y Mason
Leukemia 19: 856-861; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403702
Miscellaneous (PNH)
Differential gene expression in hematopoietic progenitors from paroxysmal nocturnal hemoglobinuria patients reveals an apoptosis/immune response in 'normal' phenotype cells
G Chen, W Zeng, J P Maciejewski, K Kcyvanfar, E M Billings and N S Young
Leukemia 19: 862-868; advance online publication, March 10, 2005; doi:10.1038/sj.leu.2403678
Correspondence
Severe irreversible bilateral hearing loss after bortezomib (VELCADE®) therapy in a multiple myeloma (MM) patient
M Engelhardt, A M S Müller, W Maier and R Wäsch
Leukemia 19: 869-870; advance online publication, March 17, 2005; doi:10.1038/sj.leu.2403723
Mcl-1 gene promoter insertions do not correlate with disease outcome, stage or VH gene mutation status in chronic lymphocytic leukaemia
G Tobin, Å Skogsberg, U Thunberg, A Laurell, A Åleskog, M Merup, C Sundström, G Roos, K Nilsson and R Rosenquist
Leukemia 19: 871-873; advance online publication, March 10, 2005; doi:10.1038/sj.leu.2403715
Pathology and clinical features of angioimmunoblastic T-cell lymphoma after successful treatment with thalidomide
A Dogan, L S P Ngu, S H Ng and P L Cervi
Leukemia 19: 873-875; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403710
Transfer of genomics information to flow cytometry: expression of CD27 and CD44 discriminates subtypes of acute lymphoblastic leukemia
M Vaskova, E Mejstrikova, T Kalina, P Martinkova, M Omelka, J Trka, J Stary and O Hrusak
Leukemia 19: 876-878; advance online publication, March 10, 2005; doi:10.1038/sj.leu.2403706
Outcome of myeloablative allogeneic stem cell transplantation in multiple myeloma with a 153Sm-EDTMP-based preparative regimen
G A Kennedy, S Durrant, J Butler, J Morton, R Western, M L Bartlett, R Allison and D J MacFarlane
Leukemia 19: 879-880; advance online publication, March 10, 2005; doi:10.1038/sj.leu.2403698
Absence of ATM hypermethylation in mantle cell and follicular lymphoma
C S Chim, K Y Wong, F Loong and G Srivastava
Leukemia 19: 880-882; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403676
Levels of soluble CD137 are enhanced in sera of leukemia and lymphoma patients and are strongly associated with chronic lymphocytic leukemia
M Furtner, R H Straub, S Krüger and H Schwarz
Leukemia 19: 883-885; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403675
Acute myeloid leukemias with recurrent genetic abnormalities: frequent assessment of minimal residual disease and treatment of molecular relapse with chemotherapy
M Doubek, Y Brychtova, J Berkovcova, M Krejci, I Palasek, D Dvorakova and J Mayer
Leukemia 19: 885-888; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403708
PRV-1 and its correlation with treatments and disease status in 210 patients with polycythemia vera and essential thrombocythemia
F Passamonti, D Pietra, E Rumi, L Arcaini, M G Della Porta, L Malcovati, C Pascutto, M Lazzarino and M Cazzola
Leukemia 19: 888-889; advance online publication, March 3, 2005; doi:10.1038/sj.leu.2403700
