TABLE OF CONTENTS
Volume 19, Issue 3 (March 2005)
Keynote Address: Acute Leukemia Forum, San Francisco, 16 April 2004 |
Review |
Debate Round Table |
Spotlight on Angiogenesis |
Commentary |
Original Manuscripts |
Spotlight Correspondence |
Correspondence
Editorial
Development of a regional flow cytometry center for diagnosis of childhood leukemia in Central America
S C Howard, D Campana, E Coustan-Smith, F G Antillon, M Bonilla, L Fu, C -H Pui, R C Ribeiro, J A Wilimas and R Lorenzana
Leukemia 19: 323-325; doi:10.1038/sj.leu.2403624
Keynote Address: Acute Leukemia Forum, San Francisco, 16 April 2004
Clinical and biological features of favorable-risk acute myelogenous leukemia – is favorable-risk AML really favorable?
G J Schiller
Leukemia 19: 326-328; advance online publication, February 3, 2005; doi:10.1038/sj.leu.2403659
Review
CEBPA point mutations in hematological malignancies
H Leroy, C Roumier, P Huyghe, V Biggio, P Fenaux and C Preudhomme
Leukemia 19: 329-334; advance online publication, January 13, 2005; doi:10.1038/sj.leu.2403614
Debate Round Table
Chimerism testing after allogeneic stem cell transplantation: importance of timing and optimal technique for testing in different clinical–biological situations
Thomas Lion MD, PhD and Nicole Muller-Bérat MD, PhD
Leukemia 19: 335; advance online publication, January 20, 2005; doi:10.1038/sj.leu.2403637
Reliable quantification of hematopoietic chimerism after allogeneic transplantation for acute leukemia using amplification by real-time PCR of null alleles and insertion/deletion polymorphisms
A Jiménez-Velasco, M Barrios, J Román-Gómez, G Navarro, I Buño, J A Castillejo, A I Rodríguez, G García-Gemar, A Torres and A I Heiniger
Leukemia 19: 336-343; advance online publication, January 20, 2005; doi:10.1038/sj.leu.2403622
Spotlight on Angiogenesis
VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli
L Wang, L Chen, J Benincosa, J Fortney and L F Gibson
Leukemia 19: 344-353; advance online publication, February 3, 2005; doi:10.1038/sj.leu.2403643
Commentary
Dendritic cells in MDS and AML – cause, effect or solution to the immune pathogenesis of disease?
N Panoskaltsis
Leukemia 19: 354-357; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403634
Original Manuscripts
Molecular Cytogenetics
A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias
F Speleman, B Cauwelier, N Dastugue, J Cools, B Verhasselt, B Poppe, N Van Roy, J Vandesompele, C Graux, A Uyttebroeck, M Boogaerts, B De Moerloose, Y Benoit, D Selleslag, J Billiet, A Robert, F Huguet, P Vandenberghe, A De Paepe, P Marynen and A Hagemeijer
Leukemia 19: 358-366; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403657
Prognostic value of real-time quantitative PCR (RQ-PCR) in AML with t(8;21)
H Leroy, S de Botton, N Grardel-Duflos, S Darre, X Leleu, C Roumier, F Morschhauser, J -L Lai, F Bauters, P Fenaux and C Preudhomme
Leukemia 19: 367-372; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403627
BCR/ABL Studies
BCR/ABL-mediated downregulation of genes implicated in cell adhesion and motility leads to impaired migration toward CCR7 ligands CCL19 and CCL21 in primary BCR/ABL-positive cells
M Jongen-Lavrencic, S Salesse, R Delwel and C M Verfaillie
Leukemia 19: 373-380; advance online publication, January 13, 2005; doi:10.1038/sj.leu.2403626
CML
Dysregulated expression of the major telomerase components in leukaemic stem cells
M W Drummond, S F Hoare, A Monaghan, S M Graham, M J Alcorn, W N Keith and T L Holyoake
Leukemia 19: 381-389; advance online publication, January 20, 2005; doi:10.1038/sj.leu.2403616
APL
WEB-2086 and WEB-2170 trigger apoptosis in both ATRA-sensitive and -resistant promyelocytic leukemia cells and greatly enhance ATRA differentiation potential
A Laurenzana, C Cellai, A M Vannucchi, A Pancrazzi, M N Romanelli and F Paoletti
Leukemia 19: 390-395; advance online publication, January 13, 2005; doi:10.1038/sj.leu.2403618
MDS
Value of chemotherapy before allogeneic hematopoietic stem cell transplantation from an HLA-identical sibling donor for myelodysplastic syndrome
K Nakai, Y Kanda, S Fukuhara, H Sakamaki, S Okamoto, Y Kodera, R Tanosaki, S Takahashi, T Matsushima, Y Atsuta, N Hamajima, M Kasai and S Kato
Leukemia 19: 396-401; advance online publication, January 13, 2005; doi:10.1038/sj.leu.2403640
Gene Expression Profile in AML
Gene expression profile reveals deregulation of genes with relevant functions in the different subclasses of acute myeloid leukemia
N C Gutiérrez, R López-Pérez, J M Hernández, I Isidro, B González, M Delgado, E Fermiñán, J L García, L Vázquez, M González and J F San Miguel
Leukemia 19: 402-409; advance online publication, January 20, 2005; doi:10.1038/sj.leu.2403625
Childhood AML
CEBP
mutations in childhood acute myeloid leukemia
D -C Liang, L -Y Shih, C -F Huang, I -J Hung, C -P Yang, H -C Liu, T -H Jaing, L -Y Wang and W -H Chang
Leukemia 19: 410-414; advance online publication, December 23, 2004; doi:10.1038/sj.leu.2403608
Etio-Pathogenesis of Childhood Leukemia
RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia
J L Wiemels, Y Zhang, J Chang, S Zheng, C Metayer, L Zhang, M T Smith, X Ma, S Selvin, P A Buffler and J K Wiencke
Leukemia 19: 415-419; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403641
Asparagine Synthetase
Epigenetic changes in the repression and induction of asparagine synthetase in human leukemic cell lines
Y Ding, Z Li and J D Broome
Leukemia 19: 420-426; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403639
CLL
Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation
W J M Mackus, A P Kater, A Grummels, L M Evers, B Hooijbrink, M H H Kramer, J E Castro, T J Kipps, R A W van Lier, M H J van Oers and E Eldering
Leukemia 19: 427-434; advance online publication, January 20, 2005; doi:10.1038/sj.leu.2403623
CML as a Human Model in Mice
Different subsets of primary chronic myeloid leukemia stem cells engraft immunodeficient mice and produce a model of the human disease
W Eisterer, X Jiang, O Christ, H Glimm, K H Lee, E Pang, K Lambie, G Shaw, T L Holyoake, A L Petzer, C Auewarakul, M J Barnett, C J Eaves and A C Eaves
Leukemia 19: 435-441; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403649
BCR-ABL-transduced human cord blood cells produce abnormal populations in immunodeficient mice
Y Chalandon, X Jiang, O Christ, S Loutet, E Thanopoulou, A Eaves and C Eaves
Leukemia 19: 442-448; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403650
Myeloma
Clonal plasma cells from monoclonal gammopathy of undetermined significance, multiple myeloma and plasma cell leukemia show different expression profiles of molecules involved in the interaction with the immunological bone marrow microenvironment
M Pérez-Andrés, J Almeida, M Martín-Ayuso, M J Moro, G Martín-Nuñez, J Galende, D Borrego, M J Rodríguez, F Ortega, J Hernandez, I Moreno, M Domínguez, G Mateo, J F San Miguel and A Orfao for the Spanish Network on multiple myeloma (G03/136) and the Spanish Network of Cancer Research Centers (C03/10)
Leukemia 19: 449-455; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403647
Spotlight Correspondence
Does post-transplant treatment with imatinib mesylate inhibit graft-versus-leukemia?
S Chunduri, L C Dobogai, A Bruno, S Kadkol and D Rondelli
Leukemia 19: 456-457; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403656
Reply to 'Does post-transplant treatment with imatinib mesylate inhibit graft-versus-leukemia?' by Chunduri et al
K Cwynarski, J V Melo and F Dazzi
Leukemia 19: 457; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403658
Gene expression profiling of Philadelphia chromosome (Ph)-negative CD34+ hematopoietic stem and progenitor cells of patients with Ph-positive CML in major molecular remission during therapy with imatinib
F Neumann, N Teutsch, S Kliszewski, S Bork, U Steidl, B Brors, N Schimkus, N Roes, U Germing, B Hildebrandt, B Royer-Pokora, R Eils, N Gattermann, R Haas and R Kronenwett
Leukemia 19: 458-460; advance online publication, December 23, 2004; doi:10.1038/sj.leu.2403615
Clonal aberrations in Philadelphia chromosome negative hematopoiesis in patients with chronic myeloid leukemia treated with imatinib or interferon alpha
U Bacher, A Hochhaus, U Berger, W Hiddemann, R Hehlmann, T Haferlach and C Schoch
Leukemia 19: 460-463; advance online publication, December 30, 2004; doi:10.1038/sj.leu.2403607
Correspondence
Absence of H2AX gene mutations in B-cell leukemias and lymphomas
S H Walsh and R Rosenquist
Leukemia 19: 464; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403651
Loci other than 21q22.12 (RUNX1) and 16q21–23.2 cause familial AML
G S Sellick, K Pritchard-Jones, V Shepherd, J Swansbury, D Catovsky and R S Houlston
Leukemia 19: 465-466; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403648
FLT3 mutations in childhood acute lymphoblastic leukemia at first relapse
S Wellmann, E Moderegger, A Zelmer, M Bettkober, A von Stackelberg, G Henze and K Seeger
Leukemia 19: 467-468; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403655
NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance
P Ballerini, M Busson, S Fasola, J van den Akker, H Lapillonne, S P Romana, P Marynen, O A Bernard, J Landman-Parker and R Berger
Leukemia 19: 468-470; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403654
Molecular and cytogenetic characterization of a new case of t(5;17)(q35;q21) variant acute promyelocytic leukemia
C Nicci, E Ottaviani, S Luatti, T Grafone, M Tonelli, M R Motta, M Malagola, G Marzocchi, G Martinelli, M Baccarani and N Testoni
Leukemia 19: 470-472; advance online publication, January 27, 2005; doi:10.1038/sj.leu.2403645
Treatment of herpesvirus associated primary effusion lymphoma with intracavity cidofovir
M Luppi, R Trovato, P Barozzi, D Vallisa, G Rossi, A Re, L Ravazzini, L Potenza, G Riva, M Morselli, G Longo, L Cavanna, R Roncaglia and G Torelli
Leukemia 19: 473-476; advance online publication, January 20, 2005; doi:10.1038/sj.leu.2403646
Novel missense mutations in the tyrosine kinase domain of the platelet-derived growth factor receptor 
(PDGFRA) gene in childhood acute myeloid leukemia with t(8;21)(q22;q22) or inv(16)(p13q22)
M Hiwatari, T Taki, M Tsuchida, R Hanada, T Hongo, M Sako and Y Hayashi
Leukemia 19: 476-477; advance online publication, January 20, 2005; doi:10.1038/sj.leu.2403638
Successful oral valganciclovir treatment of cytomegalovirus infection during Campath-1H therapy
H González, J P Vernant and E Caumes
Leukemia 19: 478; advance online publication, December 23, 2004; doi:10.1038/sj.leu.2403636
Multiple relapses and extramedullary localization with scalp and breast involvement in a case of acute promyelocytic leukaemia
E Ammatuna, P A Borza, A P Iori, M C Petti, E Pescarmona, D Diverio and F Lo-Coco
Leukemia 19: 479-480; advance online publication, January 20, 2005; doi:10.1038/sj.leu.2403632
A novel FLT3 activation loop mutation N841K in acute myeloblastic leukemia
N Matsuno, T Nanri, T Kawakita, H Mitsuya and N Asou
Leukemia 19: 480-481; advance online publication, December 30, 2004; doi:10.1038/sj.leu.2403630
Phenotypic and functional relationship between adult T-cell leukemia cells and regulatory T cells
Y Matsubara, T Hori, R Morita, S Sakaguchi and T Uchiyama
Leukemia 19: 482-483; advance online publication, January 13, 2005; doi:10.1038/sj.leu.2403628
The antiapoptotic member of the Bcl-2 family Mcl-1 is a CTL target in cancer patients
M H Andersen, J C Becker and P thor Straten
Leukemia 19: 484-485; advance online publication, December 16, 2004; doi:10.1038/sj.leu.2403621
Cytolytic activity against primary leukemic cells by inhibitory NK cell receptor (CD94/NKG2A)-expressing T cells expanded from various sources of blood mononuclear cells
J Tanaka, N Iwao, T Toubai, Y Tsutsumi, Y Miura, N Kato, A Shigematsu, M Yamane, S Ota, T Kondo, T Kobayashi, H Takeda, M Kobayashi, M Asaka and M Imamura
Leukemia 19: 486-489; advance online publication, December 23, 2004; doi:10.1038/sj.leu.2403611
Cellular in vitro immune function in multiple myeloma patients after high-dose chemotherapy and autologous peripheral stem cell transplantation
M Lindemann, P Schuett, T Moritz, H D Ottinger, B Opalka, S Seeber, M R Nowrousian and H Grosse-Wilde
Leukemia 19: 490-492; advance online publication, January 13, 2005; doi:10.1038/sj.leu.2403633
Relative quantification of residual tumor cells by lightcycler real-time IgH PCR in autografted multiple myeloma patients
V Rimelen, C Ferrand, A Debecker, H Sovalat, C Tancredi, A Eidenschenk and P Hénon
Leukemia 19: 492-495; advance online publication, December 30, 2004; doi:10.1038/sj.leu.2403620
