Treatment strategies and long-term results in paediatric patients treated in four consecutive AML-BFM trials

U Creutzig, M Zimmermann, J Ritter, D Reinhardt, J Hermann, G Henze, H Jürgens, H Kabisch, A Reiter, H Riehm, H Gadner and G Schellong for the AML-BFM Study Group

Leukemia 19: 2030-2042; advance online publication, September 15, 2005; doi:10.1038/sj.leu.2403920

Abstract | Full Text | PDF | Supplementary information

Treatment and long-term results in children with acute myeloid leukaemia treated according to the AIEOP AML protocols

A Pession, R Rondelli, G Basso, C Rizzari, A M Testi, F Fagioli, P De Stefano, F Locatelli and and on behalf of the AML Strategy & Study Committee of the Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP)

Leukemia 19: 2043-2053; advance online publication, August 18, 2005; doi:10.1038/sj.leu.2403869

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Long-term results of children with acute myeloid leukemia: a report of three consecutive Phase III trials by the Children's Cancer Group: CCG 251, CCG 213 and CCG 2891

F O Smith, T A Alonzo, R B Gerbing, W G Woods and R J Arceci for the Children's Cancer Group

Leukemia 19: 2054-2062; advance online publication, September 1, 2005; doi:10.1038/sj.leu.2403925

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Treatment strategy and results in children treated on three Dutch Childhood Oncology Group acute myeloid leukemia trials

G Kardos, C M Zwaan, G J L Kaspers, S S N de-Graaf, E S J M de Bont, A Postma, J P M Bökkerink, R S Weening, A van der Does-van den Berg, E R van Wering, C Korbijn and K Hählen

Leukemia 19: 2063-2071; advance online publication, August 18, 2005; doi:10.1038/sj.leu.2403873

Abstract | Full Text | PDF | Supplementary information

Results of 58872 and 58921 trials in acute myeloblastic leukemia and relative value of chemotherapy vs allogeneic bone marrow transplantation in first complete remission: the EORTC Children Leukemia Group report

N Entz-Werle, S Suciu, J van der Werff ten Bosch, E Vilmer, Y Bertrand, Y Benoit, G Margueritte, E Plouvier, P Boutard, E Vandecruys, A Ferster, P Lutz, A Uyttebroeck, C Hoyoux, A Thyss, X Rialland, L Norton, M-P Pages, N Philippe, J Otten and C Behar on behalf of EORTC Children Leukemia Group (CLG)

Leukemia 19: 2072-2081; advance online publication, September 1, 2005; doi:10.1038/sj.leu.2403932

Abstract | Full Text | PDF | Supplementary information

Treatment of childhood acute myeloblastic leukemia: dose intensification improves outcome and maintenance therapy is of no benefit – multicenter studies of the French LAME (Leucémie Aiguë Myéloblastique Enfant) Cooperative Group

Y Perel, A Auvrignon, T Leblanc, G Michel, Y Reguerre, J-P Vannier, J-H Dalle, V Gandemer, C Schmitt, F Méchinaud, O Lejars, C Piguet, G Couillaud, B Pautard, J Landman-Parker, I Thuret, N Aladjidi, A Baruchel and G Leverger for the Group LAME of the Société Française des Cancers de l'Enfant (SFCE), France

Leukemia 19: 2082-2089; advance online publication, August 25, 2005; doi:10.1038/sj.leu.2403867

Abstract | Full Text | PDF | Supplementary information

Long-term results in children with AML: NOPHO-AML Study Group – report of three consecutive trials

S O Lie, J Abrahamsson, N Clausen, E Forestier, H Hasle, L Hovi, G Jonmundsson, L Mellander, M A Siimes, M Yssing, B Zeller and G Gustafsson on behalf of the Nordic Society of Pediatric Hematology and Oncology (NOPHO)

Leukemia 19: 2090-2100; doi:10.1038/sj.leu.2403962

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Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): a review of four consecutive childhood AML trials conducted between 1981 and 2000

Y Ravindranath, M Chang, C P Steuber, D Becton, G Dahl, C Civin, B Camitta, A Carroll, S C Raimondi and H J Weinstein for the Pediatric Oncology Group

Leukemia 19: 2101-2116; advance online publication, September 1, 2005; doi:10.1038/sj.leu.2403927

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Twenty years of Polish experience with three consecutive protocols for treatment of childhood acute myelogenous leukemia

A Dluzniewska, W Balwierz, J Armata, A Balcerska, A Chybicka, J Kowalczyk, M Matysiak, M Ochocka, U Radwanska, R Rokicka-Milewska, D Sonta-Jakimczyk, J Wachowiak and M Wysocki for the Polish Pediatric Leukemia/Lymphoma Study Group (PPLLSG)

Leukemia 19: 2117-2124; advance online publication, September 29, 2005; doi:10.1038/sj.leu.2403892

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Successive clinical trials for childhood acute myeloid leukemia at St Jude Children's Research Hospital, from 1980 to 2000

R C Ribeiro, B I Razzouk, S Pounds, N Hijiya, C-H Pui and J E Rubnitz

Leukemia 19: 2125-2129; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2403872

Abstract | Full Text | PDF | Supplementary information

Treatment strategy and long-term results in pediatric patients treated in two consecutive AML-GATLA trials

H Armendariz, M A Fernandez Barbieri, D Freigeiro, F Lastiri, M S Felice and E Dibar on behalf of the GATLA Group Buenos Aires, Argentina

Leukemia 19: 2139-2142; doi:10.1038/sj.leu.2403854

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The evolving role of Alemtuzumab in management of patients with CLL

S Faderl, S Coutré, J C Byrd, C Dearden, A Denes, M J S Dyer, S A Gregory, J G Gribben, P Hillmen, M Keating, S Rosen, P Venugopal and K Rai

Leukemia 19: 2147-2152; advance online publication, October 20, 2005; doi:10.1038/sj.leu.2403984

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Selecting and deselecting imatinib-resistant clones: observations made by longitudinal, quantitative monitoring of mutated BCR-ABL

F X E Gruber, T Lamark, A Ånonli, M A Sovershaev, M Olsen, T Gedde-Dahl, H Hjort-Hansen and B Skogen

Leukemia 19: 2159-2165; advance online publication, October 13, 2005; doi:10.1038/sj.leu.2403983

Abstract | Full Text | PDF | Supplementary information

Growth factors and antiapoptotic signaling pathways in multiple myeloma

N W C J van de Donk, H M Lokhorst and A C Bloem

Leukemia 19: 2177-2185; advance online publication, October 20, 2005; doi:10.1038/sj.leu.2403970

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Acute Non-Lymphocytic Leukemia (ANLL)

TNF stimulates NKG2D-mediated lytic activity of acute myeloid leukemic cells

F Guilloton, A de Thonel, C Jean, C Demur, V Mansat-De Mas, G Laurent and A Quillet-Mary

Leukemia 19: 2206-2214; advance online publication, October 20, 2005; doi:10.1038/sj.leu.2403952

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Activated natural killer cells from patients with acute myeloid leukemia are cytotoxic against autologous leukemic blasts in NOD/SCID mice

U Siegler, C P Kalberer, P Nowbakht, S Sendelov, S Meyer-Monard and A Wodnar-Filipowicz

Leukemia 19: 2215-2222; advance online publication, October 13, 2005; doi:10.1038/sj.leu.2403985

Abstract | Full Text | PDF | Supplementary information

Myelodysplasias (MDS)

Refinement of the international prognostic scoring system (IPSS) by including LDH as an additional prognostic variable to improve risk assessment in patients with primary myelodysplastic syndromes (MDS)

U Germing, B Hildebrandt, M Pfeilstöcker, T Nösslinger, P Valent, C Fonatsch, M Lübbert, D Haase, C Steidl, O Krieger, R Stauder, A A N Giagounidis, C Strupp, A Kündgen, T Mueller, R Haas, N Gattermann and C Aul

Leukemia 19: 2223-2231; advance online publication, September 29, 2005; doi:10.1038/sj.leu.2403963

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Therapy-Related Leukemias

Mutations of genes in the receptor tyrosine kinase (RTK)/RAS-BRAF signal transduction pathway in therapy-related myelodysplasia and acute myeloid leukemia

D H Christiansen, M K Andersen, F Desta and J Pedersen-Bjergaard

Leukemia 19: 2232-2240; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2404009

Abstract | Full Text | PDF | Supplementary information

Acute Promyelocytic Leukemia (APL)

Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia

C-S Chim, S-Y Wong, A Pang, P Chu, J S Lau, K-F Wong and Y-L Kwong

Leukemia 19: 2241-2246; advance online publication, October 20, 2005; doi:10.1038/sj.leu.2403937

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T-Cell Leukemia and Lymphoma (TCL and T Lymphoma)

FOXP3, a selective marker for a subset of adult T-cell leukaemia/lymphoma

G Roncador, J F Garcia, J F Garcia, L Maestre, E Lucas, J Menarguez, K Ohshima, S Nakamura, A H Banham and M A Piris

Leukemia 19: 2247-2253; advance online publication, September 29, 2005; doi:10.1038/sj.leu.2403965

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Differential expression of NF-B pathway genes among peripheral T-cell lymphomas

B Martínez-Delgado, M Cuadros, E Honrado, A Ruiz de la Parte, G Roncador, J Alves, J M Castrillo, C Rivas, J Benítez and and The Spanish Cooperative Group for the study of T-cell lymphomas

Leukemia 19: 2254-2263; advance online publication, November 3, 2005; doi:10.1038/sj.leu.2403960

Abstract | Full Text | PDF | Supplementary information

Chronic Lymphocytic Leukemia, Normal T and B cells (CLL)

CD38 expression levels in chronic lymphocytic leukemia B cells are associated with activation marker expression and differential responses to interferon stimulation

B T Pittner, T D Shanafelt, N E Kay and D F Jelinek

Leukemia 19: 2264-2272; advance online publication, October 6, 2005; doi:10.1038/sj.leu.2403975

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Evidence for involvement of clonally expanded CD8⁺ T cells in anticancer immune responses in CLL patients following nonmyeloablative conditioning and hematopoietic cell transplantation

T Kollgaard, S L Petersen, S Reker Hadrup, T N Masmas, T Seremet, M H Andersen, H O Madsen, L Vindeløv and P thor Straten

Leukemia 19: 2273-2280; advance online publication, October 6, 2005; doi:10.1038/sj.leu.2403972

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Sensitivity and Resitance to Therapy

Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cells

W Bardenheuer, K Lehmberg, I Rattmann, A Brueckner, A Schneider, U R Sorg, S Seeber, T Moritz and M Flasshove

Leukemia 19: 2281-2288; doi:10.1038/sj.leu.2403977

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Oncogene

Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity

C J Betti, M J Villalobos, Q Jiang, E Cline, M O Diaz, G Loredo and A T M Vaughan

Leukemia 19: 2289-2295; advance online publication, September 29, 2005; doi:10.1038/sj.leu.2403966

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Apoptosis

CD44 ligation induces apoptosis via caspase- and serine protease-dependent pathways in acute promyelocytic leukemia cells

E Maquarre, C Artus, Z Gadhoum, C Jasmin, F Smadja-Joffe and J Robert-Lézénès

Leukemia 19: 2296-2303; advance online publication, October 6, 2005; doi:10.1038/sj.leu.2403944

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Stem Cell Transplantation (SCT)

Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT)

M Aoudjhane, M Labopin, N C Gorin, A Shimoni, T Ruutu, H-J Kolb, F Frassoni, J M Boiron, J L Yin, J Finke, H Shouten, D Blaise, M Falda, A A Fauser, J Esteve, E Polge, S Slavin, D Niederwieser, A Nagler and V Rocha on behalf of the Acute Leukemia Working Party of EBMT

Leukemia 19: 2304-2312; advance online publication, September 29, 2005; doi:10.1038/sj.leu.2403967

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Lymphoma

Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas

E Galteland, E A Sivertsen, D H Svendsrud, L Smedshammer, S H Kresse, L A Meza-Zepeda, O Myklebost, Z Suo, D Mu, P M DeAngelis and T Stokke

Leukemia 19: 2313-2323; advance online publication, September 29, 2005; doi:10.1038/sj.leu.2403954

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Myeloma

Sensitivity of human multiple myelomas and myeloid leukemias to the proteasome inhibitor I

F Servida, D Soligo, D Delia, C Henderson, C Brancolini, L Lombardi and G Lambertenghi Deliliers

Leukemia 19: 2324-2331; advance online publication, October 13, 2005; doi:10.1038/sj.leu.2403987

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D276G mutation is associated with a poor prognosis in imatinib mesylate-resistant chronic myeloid leukemia patients

T Leguay, V Desplat, G Marit and F-X Mahon

Leukemia 19: 2332-2333; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2403993

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Response to 'D276G mutation is associated with a poor prognosis in imatinib mesylate-resistant chronic myeloid leukemia patients' by Leguay et al

R G Piazza, V Magistroni, A Franceschino and C Gambacorti-Passerini

Leukemia 19: 2333-2334; advance online publication, October 20, 2005; doi:10.1038/sj.leu.2403994

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IgH/TCR rearrangements are common in MLL translocated adult AML and suggest an early T/myeloid or B/myeloid maturation arrest, which correlates with the MLL partner

C Dupret, V Asnafi, D Leboeuf, C Millien, R Ben Abdelali, C Preudhomme, K Beldjord, E Delabesse and E Macintyre

Leukemia 19: 2337-2338; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2403981

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Identification of a new monoclonal B-cell subset in unaffected first-degree relatives in familial chronic lymphocytic leukemia

T Aurran-Schleinitz, W Telford, S Perfetto, N Caporaso, W Wilson, M A Stetler-Stevenson, V E Zenger, F Abbasi and G E Marti

Leukemia 19: 2339-2341; advance online publication, October 6, 2005; doi:10.1038/sj.leu.2403980

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Familial aggregation of lymphoplasmacytic lymphoma with non-Hodgkin lymphoma and other neoplasms

A Altieri, J L Bermejo and K Hemminki

Leukemia 19: 2342-2343; advance online publication, October 13, 2005; doi:10.1038/sj.leu.2403991

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Detection of MOZ-CBP fusion in acute myeloid leukemia with 8;16 translocation

J A Crowley, Y Wang, A P Rapoport and Y Ning

Leukemia 19: 2344-2345; advance online publication, September 29, 2005; doi:10.1038/sj.leu.2403971

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The MIF-173G/C polymorphism does not contribute to prednisone poor response in vivo in childhood acute lymphoblastic leukemia

O Ziino, L E D'Urbano, F De Benedetti, V Conter, E Barisone, G De Rossi, G Basso and M Aricò for the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP)

Leukemia 19: 2346-2347; advance online publication, October 6, 2005; doi:10.1038/sj.leu.2403973

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Downregulation of the large tumor suppressor 2 (LATS2/KPM) gene is associated with poor prognosis in acute lymphoblastic leukemia

A Jiménez-Velasco, J Román-Gómez, X Agirre, M Barrios, G Navarro, I Vázquez, F Prósper, A Torres and A Heiniger

Leukemia 19: 2347-2350; advance online publication, October 6, 2005; doi:10.1038/sj.leu.2403974

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Reply to van der Sluijs-Gelling et al

G Gaipa, G Basso, R Ratei, A Biondi and M Dworzak

Leukemia 19: 2351-2352; doi:10.1038/sj.leu.2403912

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Infrequent epigenetic dysregulation of CIP/KIP family of cyclin-dependent kinase inhibitors in multiple myeloma

C S Chim, R Liang, T K Fung and Y L Kwong

Leukemia 19: 2352-2355; advance online publication, November 10, 2005; doi:10.1038/sj.leu.2403904

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Acquired Isodisomy for chromosome 13 is common in AML, and associated with FLT3-itd mutations

M Griffiths, J Mason, M Rindl, S Akiki, D McMullan, V Stinton, H Powell, A Curtis, N Bown and C Craddock

Leukemia 19: 2355-2358; advance online publication, October 20, 2005; doi:10.1038/sj.leu.2403988

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The JAK2 V617F tyrosine kinase mutation in myelodysplastic syndromes (MDS) developing myelofibrosis indicates the myeloproliferative nature in a subset of MDS patients

K Ohyashiki, Y Aota, D Akahane, A Gotoh, K Miyazawa, Y Kimura and J H Ohyashiki

Leukemia 19: 2359-2360; advance online publication, October 20, 2005; doi:10.1038/sj.leu.2403989

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Angiogenesis and mast cells in Hodgkin lymphoma

I Glimelius, A Edström, M Fischer, G Nilsson, C Sundström, D Molin, R-M Amini and G Enblad

Leukemia 19: 2360-2362; advance online publication, October 13, 2005; doi:10.1038/sj.leu.2403992

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Aberrant somatic hypermutation in primary mediastinal large B-cell lymphoma

D Rossi, M Cerri, D Capello, C Deambrogi, E Berra, S Franceschetti, O Alabiso, A Gloghini, M Paulli, A Carbone, S A Pileri, L Pasqualucci and G Gaidano

Leukemia 19: 2363-2366; advance online publication, October 6, 2005; doi:10.1038/sj.leu.2403982

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A rare case of acute myeloid leukemia with a CHIC2-ETV6 fusiongen and multiple other molecular aberrations

F Kuchenbauer, C Schoch, E Holler, T Haferlach, W Hiddemann and S Schnittger

Leukemia 19: 2366-2368; advance online publication, October 13, 2005; doi:10.1038/sj.leu.2403957

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