TABLE OF CONTENTS

Volume 19, Issue 11 (November 2005)

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Spotlight

A single nucleotide polymorphism in the coding region of ABL and its effects on sensitivity to imatinib

L C Crossman, T O'Hare, T Lange, S G Willis, E P Stoffregen, A S Corbin, S G O'Brien, M C Heinrich, B J Druker, P G Middleton and M W N Deininger

Leukemia 19: 1859-1862; advance online publication, September 8, 2005; doi:10.1038/sj.leu.2403935

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Reviews

Antigen-specific cellular immunotherapy of leukemia FREE

A Van Driessche, L Gao, H J Stauss, P Ponsaerts, D R Van Bockstaele, Z N Berneman and V F I Van Tendeloo

Leukemia 19: 1863-1871; advance online publication, August 25, 2005; doi:10.1038/sj.leu.2403930

Dual tyrosine kinase inhibitors in chronic myeloid leukemia

G Martinelli, S Soverini, G Rosti and M Baccarani

Leukemia 19: 1872-1879; advance online publication, September 22, 2005; doi:10.1038/sj.leu.2403950

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Original Manuscripts

Therapy

Cyclophosphamide followed by fludarabine for untreated chronic lymphocytic leukemia: a phase II SWOG TRIAL 9706

M A Hussein, H Gundacker, D R Head, L Elias, K A Foon, D H Boldt, S M Dobin, S R Dakhil, G T Budd and F R Appelbaum

Leukemia 19: 1880-1886; advance online publication, September 29, 2005; doi:10.1038/sj.leu.2403940

T-Cell Leukemias

Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia

M Meier, M L den Boer, A G Hall, J A E Irving, M Passier, L Minto, E R van Wering, G E Janka-Schaub and R Pieters

Leukemia 19: 1887-1895; advance online publication, September 15, 2005; doi:10.1038/sj.leu.2403943

CME, BCR/ABL Studies and Myeloproliferative Disorders

Zoledronate inhibits proliferation and induces apoptosis of imatinib-resistant chronic myeloid leukaemia cells

C Chuah, D J Barnes, M Kwok, A Corbin, M W N Deininger, B J Druker and J V Melo

Leukemia 19: 1896-1904; advance online publication, September 15, 2005; doi:10.1038/sj.leu.2403949

Imatinib mesylate suppresses cytokine synthesis by activated CD4 T cells of patients with chronic myelogenous leukemia

H Gao, B-N Lee, M Talpaz, N J Donato, J E Cortes, H M Kantarjian and J M Reuben

Leukemia 19: 1905-1911; advance online publication, September 8, 2005; doi:10.1038/sj.leu.2403933

Myelodysplesias

Risk factors of myelodysplastic syndromes: a case–control study

S S Strom, Y Gu, S K Gruschkus, S A Pierce and E H Estey

Leukemia 19: 1912-1918; advance online publication, September 15, 2005; doi:10.1038/sj.leu.2403945

Therapy-related leukemia: clinical characteristics and analysis of new molecular risk factors in 96 adult patients FREE

D Rund, S Krichevsky, S Bar-Cohen, N Goldschmidt, M Kedmi, E Malik, A Gural, S Shafran-Tikva, S Ben-Neriah and D Ben-Yehuda

Leukemia 19: 1919-1928; advance online publication, September 15, 2005; doi:10.1038/sj.leu.2403947

Low-dose cytosine arabinoside (LD-AraC) vs LD-AraC plus granulocyte/macrophage colony stimulating factor vs LD-AraC plus Interleukin-3 for myelodysplastic syndrome patients with a high risk of developing acute leukemia: final results of a randomized phase III study (06903) of the EORTC Leukemia Cooperative Group

H Zwierzina, S Suciu, J Loeffler-Ragg, R Neuwirtova, P Fenaux, M Beksac, J Harousseau, V Nuessler, J Cermak, G Solbu, R Willemze, T de Witte and S Amadori on behalf of the EORTC Leukemia Cooperative Group

Leukemia 19: 1929-1933; advance online publication, September 8, 2005; doi:10.1038/sj.leu.2403934

B-Cell Leukemia

Transfection of antisense core 2 beta1,6-N-acetylglucosaminyltransferase-1 cDNA suppresses selectin ligand expression and tissue infiltration of B-cell precursor leukemia cells

J Kikuchi, H Ozaki, C Nonomura, H Shinohara, S Iguchi, H Nojiri, H Hamada, A Kiuchi and M Nakamura

Leukemia 19: 1934-1940; advance online publication, September 22, 2005; doi:10.1038/sj.leu.2403951

Oncogenes

Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia FREE

Y-S Meng, H Khoury, J E Dick and M D Minden

Leukemia 19: 1941-1947; advance online publication, August 11, 2005; doi:10.1038/sj.leu.2403836

CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes

W A Dik, W Brahim, C Braun, V Asnafi, N Dastugue, O A Bernard, J J M van Dongen, A W Langerak, E A Macintyre and E Delabesse

Leukemia 19: 1948-1957; advance online publication, August 18, 2005; doi:10.1038/sj.leu.2403891

Differentiation

Effects of overexpression of HBP1 upon growth and differentiation of leukemic myeloid cells

C J Yao, K Works, P A Romagnoli and G E Austin

Leukemia 19: 1958-1968; advance online publication, September 22, 2005; doi:10.1038/sj.leu.2403918

Myeloma

The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteoprotegerin ratio

E Terpos, D Mihou, R Szydlo, K Tsimirika, C Karkantaris, M Politou, E Voskaridou, A Rahemtulla, M A Dimopoulos and K Zervas

Leukemia 19: 1969-1976; advance online publication, August 4, 2005; doi:10.1038/sj.leu.2403890

Lymphoma

Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation

W Zhang, T McQueen, W Schober, G Rassidakis, M Andreeff and M Konopleva

Leukemia 19: 1977-1984; advance online publication, September 8, 2005; doi:10.1038/sj.leu.2403929

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Spotlight Correspondence

Imatinib dose increase up to 1200 mg daily can induce new durable complete cytogenetic remissions in relapsed Ph+ chronic myeloid leukemia patients

R G Piazza, V Magistroni, F Andreoni, A Franceschino, L Tornaghi, M Varella-Garcia, S Bungaro, F Colnaghi, G Corneo, E M Pogliani and C Gambacorti-Passerini

Leukemia 19: 1985-1987; advance online publication, August 25, 2005; doi:10.1038/sj.leu.2403928

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Correspondence

Quantification of CBFB-MYH11 fusion gene levels in paired peripheral blood and bone marrow samples by real-time PCR

N Boeckx, J De Roover, V H J van der Velden, J Maertens, A Uyttebroeck, P Vandenberghe and J J M van Dongen

Leukemia 19: 1988-1990; advance online publication, September 29, 2005; doi:10.1038/sj.leu.2403961

Coexistence of AML1/RUNX1 and BCR-ABL point mutations in an imatinib-resistant form of CML

S Corm, V Biggio, C Roche-Lestienne, J-L Laï, I Yakoub-Agha, N Philippe, F-E Nicolini, T Facon and C Preudhomme

Leukemia 19: 1991-1992; advance online publication, September 8, 2005; doi:10.1038/sj.leu.2403931

Complete remission in a patient with relapsed angioimmunoblastic T-cell lymphoma following treatment with bevacizumab

I Bruns, F Fox, P Reinecke, G Kobbe, R Kronenwett, G Jung and R Haas

Leukemia 19: 1993-1995; advance online publication, September 8, 2005; doi:10.1038/sj.leu.2403936

MDM2 promoter variation and age of diagnosis of acute lymphoblastic leukemia

R M Swinney, S C Hsu, B A Hirschman, T T-C Chen and G E Tomlinson

Leukemia 19: 1996-1998; advance online publication, September 15, 2005; doi:10.1038/sj.leu.2403941

Prognostic impact of vascular density and fibrosis in the bone marrow of children with high-risk acute lymphoblastic leukemia

U Norén-Nyström, G Roos, A Bergh and E Forestier

Leukemia 19: 1998-2001; advance online publication, September 22, 2005; doi:10.1038/sj.leu.2403953

Gene expression profiling of chronic lymphocytic leukemia can discriminate cases with stable disease and mutated Ig genes from those with progressive disease and unmutated Ig genes

Y Vasconcelos, J De Vos, L Vallat, T Rème, A I Lalanne, K Wanherdrick, A Michel, F Nguyen-Khac, P Oppezzo, C Magnac, K Maloum, F Ajchenbaum-Cymbalista, X Troussard, M Leporrier, B Klein, G Dighiero and F Davi on behalf of the French Cooperative Group on CLL

Leukemia 19: 2002-2005; advance online publication, August 25, 2005; doi:10.1038/sj.leu.2403865

Remission of pure red cell aplasia in T-cell receptor bold italic gammadelta-large granular lymphocyte leukemia after therapy with low-dose alemtuzumab

C Schützinger, A Gaiger, R Thalhammer, M Vesely, R Fritsche-Polanz, I Schwarzinger, L Öhler, I Simonitsch-Klupp, F Reinhard and U Jäger

Leukemia 19: 2005-2008; advance online publication, September 29, 2005; doi:10.1038/sj.leu.2403956

Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia

T Sonoki, E Iwanaga, H Mitsuya and N Asou

Leukemia 19: 2009-2010; advance online publication, September 15, 2005; doi:10.1038/sj.leu.2403938

Deletion of the inositide-specific phospholipase c beta1 gene is a rare event in myelodysplastic syndrome and thus of limited value to predict leukemic progression

E Verburgh, G Verhoef, P Vandenberghe and A Hagemeijer

Leukemia 19: 2011-2013; advance online publication, September 29, 2005; doi:10.1038/sj.leu.2403964

A microRNA cluster as a target of genomic amplification in malignant lymphoma

H Tagawa and M Seto

Leukemia 19: 2013-2016; advance online publication, September 15, 2005; doi:10.1038/sj.leu.2403942

Efficient and easy detection of MLL-AF4, MLL-AF9 and MLL-ENL fusion gene transcripts by multiplex real-time quantitative RT-PCR in TaqMan and LightCycler

M W J C Jansen, V H J van der Velden and J J M van Dongen

Leukemia 19: 2016-2018; advance online publication, September 8, 2005; doi:10.1038/sj.leu.2403939

Herpes simplex virus pneumonia during standard induction chemotherapy for acute leukemia: case report and review of literature

A Ferrari, M Luppi, L Potenza, G Riva, M Morselli, A Imovilli, F Volzone, G Rossi, M Codeluppi, G Guaraldi and G Torelli

Leukemia 19: 2019-2021; advance online publication, July 28, 2005; doi:10.1038/sj.leu.2403893

CD33 is expressed on plasma cells of a significant number of myeloma patients, and may represent a therapeutic target

N Robillard, S Wuillème, L Lodé, F Magrangeas, S Minvielle and H Avet-Loiseau

Leukemia 19: 2021-2022; advance online publication, September 15, 2005; doi:10.1038/sj.leu.2403948

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Corrigendum

Abl inhibitor BMS354825 binding mode in Ableson kinase revealed by molecular docking studies FREE

C Gambacorti-Passerini, M Gasser, S Ahmed and L Scapozza

Leukemia 19: 2023; doi:10.1038/sj.leu.2403990

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