TABLE OF CONTENTS

Volume 18, Issue 8 (August 2004)

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Review

Imatinib therapy in chronic myelogenous leukemia: strategies to avoid and overcome resistance FREE

A Hochhaus and P La Rosée

Leukemia 18: 1321-1331; advance online publication, June 24, 2004; doi:10.1038/sj.leu.2403426

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Spotlights

Imatinib inhibits the activation and proliferation of normal T lymphocytes in vitro  FREE

K Cwynarski, R Laylor, E Macchiarulo, J Goldman, G Lombardi, J V Melo and F Dazzi

Leukemia 18: 1332-1339; advance online publication, June 10, 2004; doi:10.1038/sj.leu.2403401

Report of 34 patients with clonal chromosomal abnormalities in Philadelphia-negative cells during imatinib treatment of Philadelphia-positive chronic myeloid leukemia FREE

C Terre, V Eclache, P Rousselot, M Imbert, C Charrin, C Gervais, M J Mozziconacci, O Maarek, H Mossafa, N Auger, N Dastugue, P Talmant, J Van den Akker, C Leonard, F N'Guyen Khac, F Mugneret, F Viguié, M Lafage-Pochitaloff, J N Bastie, G L Roux, F Nicolini, F Maloisel, N Vey, G Laurent, C Recher, M Vigier, Y Yacouben, S Giraudier, J P Vernant, B Salles, J Roussi, S Castaigne, V Leymarie, G Flandrin and M Lessard On behalf of France Intergroupe pour la Leucemie Myeloide Chronique (FILMC)

Leukemia 18: 1340-1346; advance online publication, June 10, 2004; doi:10.1038/sj.leu.2403399

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Commentaries

Topoisomerase IIalpha as a prognostic factor in mantle cell lymphoma FREE

P Korkolopoulou and T P Vassilakopoulos

Leukemia 18: 1347-1349; advance online publication, June 17, 2004; doi:10.1038/sj.leu.2403413

The first evidence of the tumor-induced angiogenesis in vivo by using the chorioallantoic membrane assay dated 1913 FREE

Domenico Ribatti

Leukemia 18: 1350-1351; advance online publication, June 17, 2004; doi:10.1038/sj.leu.2403411

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Molecular Targets for Therapy (MTT)

Efficacy of dual-specific Bcr-Abl and Src-family kinase inhibitors in cells sensitive and resistant to imatinib mesylate FREE

A J Tipping, S Baluch, D J Barnes, D R Veach, B M Clarkson, W G Bornmann, F X Mahon, J M Goldman and J V Melo

Leukemia 18: 1352-1356; advance online publication, June 17, 2004; doi:10.1038/sj.leu.2403416

Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro  FREE

Y Satou, K Nosaka, Y Koya, J-i Yasunaga, S Toyokuni and M Matsuoka

Leukemia 18: 1357-1363; advance online publication, June 10, 2004; doi:10.1038/sj.leu.2403400

The synthetic peptide PFWT disrupts AF4–AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells FREE

R S Srinivasan, J B Nesbit, L Marrero, F Erfurth, V F LaRussa and C S Hemenway

Leukemia 18: 1364-1372; doi:10.1038/sj.leu.2403415

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Original Manuscripts

Cyclooxygenase-1, but not -2, is upregulated in NB4 leukemic cells and human primary promyelocytic blasts during differentiation FREE

B Rocca, R Morosetti, A Habib, N Maggiano, F Zassadowski, G Ciabattoni, C Chomienne, B Papp and F O Ranelletti

Leukemia 18: 1373-1379; advance online publication, June 10, 2004; doi:10.1038/sj.leu.2403407

MRD parameters using immunophenotypic detection methods are highly reliable in predicting survival in acute myeloid leukaemia FREE

N Feller, M A van der Pol, A van Stijn, G W D Weijers, A H Westra, B W Evertse, G J Ossenkoppele and G J Schuurhuis

Leukemia 18: 1380-1390; advance online publication, June 17, 2004; doi:10.1038/sj.leu.2403405

A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells FREE

S Cuní, P Pérez-Aciego, G Pérez-Chacón, J A Vargas, A Sánchez, F M Martín-Saavedra, S Ballester, J García-Marco, J Jordá and A Durántez

Leukemia 18: 1391-1400; advance online publication, June 3, 2004; doi:10.1038/sj.leu.2403398

Prevalence and clinical significance of resistance to perforin- and FAS-mediated cell death in leukemia FREE

H G Otten, W G J van Ginkel, A Hagenbeek and E J Petersen

Leukemia 18: 1401-1405; advance online publication, June 24, 2004; doi:10.1038/sj.leu.2403414

Betulinic acid-induced apoptosis in leukemia cells FREE

H Ehrhardt, S Fulda, M Führer, K M Debatin and I Jeremias

Leukemia 18: 1406-1412; advance online publication, June 17, 2004; doi:10.1038/sj.leu.2403406

Induction of differentiation of human myeloid leukemia cells by jasmonates, plant hormones FREE

Y Ishii, H Kiyota, S Sakai and Y Honma

Leukemia 18: 1413-1419; advance online publication, July 1, 2004; doi:10.1038/sj.leu.2403421

Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma FREE

E Terpos, M Politou, R Szydlo, E Nadal, S Avery, E Olavarria, E Kanfer, J M Goldman, J F Apperley and A Rahemtulla

Leukemia 18: 1420-1426; advance online publication, June 24, 2004; doi:10.1038/sj.leu.2403423

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Correspondence

Clinical features of childhood acute myeloid leukaemia with specific gene rearrangements FREE

E Frascella, R Rondelli, M Pigazzi, C Zampieron, F Fagioli, C Favre, A A Lippi, F Locatelli, M Luciani, G Menna, C Micalizzi, C Rizzari, A M Testi, A Pession and G Basso

Leukemia 18: 1427-1429; advance online publication, June 17, 2004; doi:10.1038/sj.leu.2403410

Low-dose ARAC, donor cells, and GM-CSF for treatment of recurrent acute myeloid leukemia after allogeneic stem cell transplantation FREE

C Schmid, M Schleuning, J Aschan, O Ringdén, J Hahn, E Holler, U Hegenbart, D Niederwieser, M Dugas, G Ledderose and H-J Kolb

Leukemia 18: 1430-1433; advance online publication, June 17, 2004; doi:10.1038/sj.leu.2403412

Waldenstrom's macroglobulinemia evolving into acute lymphoblastic leukemia: a case report and a review of the literature FREE

R A Madan, V T Chang, C Yook, F K Baddoura, S Srinivas and B Kasimis

Leukemia 18: 1433-1435; advance online publication, June 17, 2004; doi:10.1038/sj.leu.2403408

ETV6 (TEL) gene amplification in a myelodysplastic syndrome with excess of blasts FREE

L Mauvieux, C Helias, N Perrusson, B Lioure, N Sorel, F Brizard and M Lessard

Leukemia 18: 1436-1438; advance online publication, June 3, 2004; doi:10.1038/sj.leu.2403403

Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation FREE

Y Kubota, H Ohnishi, A Kitanaka, T Ishida and T Tanaka

Leukemia 18: 1438-1440; advance online publication, June 3, 2004; doi:10.1038/sj.leu.2403402

Development of a quantitative-PCR method for specific FLT3/ITD monitoring in acute myeloid leukemia FREE

C Beretta, G Gaipa, V Rossi, S Bernasconi, O Spinelli, M G Dell'Oro, C Rizzari, A Rambaldi, A Biondi and G Cazzaniga

Leukemia 18: 1441-1444; advance online publication, June 17, 2004; doi:10.1038/sj.leu.2403409

The paternal chromosome 9 and the maternal chromosome 22 are preferentially rearranged in chronic myeloid leukaemia FREE

R Olicio, M B Rivero and H N Seuánez

Leukemia 18: 1445-1448; advance online publication, June 10, 2004; doi:10.1038/sj.leu.2403404

Biochemical pathway of antigen processing by HLA class II molecules in B cell lymphomas FREE

N Magniez, C Roucard, J J Sotto, D Leroux and F Garban

Leukemia 18: 1448-1450; advance online publication, May 20, 2004; doi:10.1038/sj.leu.2403384

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