Leukemia

FIGURE 1

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TEL-Syk fusion constitutively activates PI3-K/Akt, MAPK and JAK2-independent STAT5 signal pathways

T Kanie, A Abe, T Matsuda, Y Kuno, M Towatari, T Yamamoto, H Saito, N Emi and T Naoe

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Figure 1.

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Schematic representation of constructed TEL-Syk and deletion mutant TELDeltaPNT-Syk (deletion of nt 222–461). For high expression in BaF3 cells, TEL-Syk and TELDeltaPNT-Syk were cloned into the pBabeNeo construct, a retroviral vector based on an MMLV-expressing neomycin-resistant gene. For immunofluorescence microscopy, TEL-Syk cDNA cloned into pFlag (the Flag epitope tagged) was used. LTR, long-terminal repeat; SV40, SV40 promoter; SV40pA, SV40 polyadenylation signal; CMV, CMV promoter.

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