TABLE OF CONTENTS

Volume 18, Issue 10 (October 2004)

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Keynote Address: Acute Leukemia Forum, San Francisco, 16 April 2004

The role of allogeneic transplantation in high-risk acute myelogenous leukemia FREE

W R Drobyski

Leukemia 18: 1565-1568; doi:10.1038/sj.leu.2403482

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Commentaries

Malignant hematopoietic cell lines: in vitro models for the study of anaplastic large-cell lymphoma FREE

H G Drexler and R A F MacLeod

Leukemia 18: 1569-1571; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403465

Is it now the time to update treatment protocols for lymphomas with new anti-virus systems? FREE

M Luppi, P Barozzi, L Potenza, G Riva, M Morselli and G Torelli

Leukemia 18: 1572-1575; advance online publication, July 29, 2004; doi:10.1038/sj.leu.2403447

Treatment of acute promyelocytic leukemia in children: arsenic or ATRA FREE

Y Ravindranath, J Gregory and J Feusner

Leukemia 18: 1576-1577; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403479

Controlling TRAIL-mediated caspase-3 activation FREE

O Micheau and D Mérino

Leukemia 18: 1578-1580; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403497

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Original Manuscripts

Therapy

Low-dose oral etoposide-based induction regimen for children with acute lymphoblastic leukemia in first bone marrow relapse FREE

N Hijiya, A Gajjar, Z Zhang, J T Sandlund, R C Ribeiro, J E Rubnitz, S Jeha, W Liu, C Cheng, S C Raimondi, F G Behm, G K Rivera, M V Relling and C-H Pui

Leukemia 18: 1581-1586; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403467

Treatment of children with newly diagnosed acute promyelocytic leukemia with arsenic trioxide: a single center experience FREE

B George, V Mathews, B Poonkuzhali, R V Shaji, A Srivastava and M Chandy

Leukemia 18: 1587-1590; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403480

Morphology

A distinctive nuclear morphology in acute myeloid leukemia is strongly associated with loss of HLA-DR expression and FLT3 internal tandem duplication FREE

S J Kussick, D L Stirewalt, H S Yi, K M Sheets, E Pogosova-Agadjanyan, S Braswell, T H Norwood, J P Radich and B L Wood

Leukemia 18: 1591-1598; advance online publication, September 2, 2004; doi:10.1038/sj.leu.2403458

CLL

Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells FREE

I Marzo, P Pérez-Galán, P Giraldo, N López-Royuela, M Gómez-Benito, L Larrad, P Lasierra, D Rubio-Félix, A Anel and J Naval

Leukemia 18: 1599-1604; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403469

Phase II study of theophylline in chronic lymphocytic leukemia: a study of the Eastern Cooperative Oncology Group (E4998) FREE

P H Wiernik, E Paietta, O Goloubeva, S J Lee, D Makower, J M Bennett, J L Wade, C Ghosh, L S Kaminer, J Pizzolo and M S Tallman for the Eastern Cooperative Oncology Group

Leukemia 18: 1605-1610; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403494

ALL

Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis FREE

A Attarbaschi, G Mann, M König, M N Dworzak, M M Trebo, N Mühlegger, H Gadner and O A Haas on behalf of the Austrian Berlin-Frankfurt-Münster (BFM) Cooperative Study Group

Leukemia 18: 1611-1616; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403471

Down Syndrome

Distinct gene signatures of transient and acute megakaryoblastic leukemia in Down syndrome FREE

J Lightfoot, J K Hitzler, A Zipursky, M Albert and P F Macgregor

Leukemia 18: 1617-1623; advance online publication, September 2, 2004; doi:10.1038/sj.leu.2403466

Leukemia in Twins

Prenatal origin of separate evolution of leukemia in identical twins FREE

O Teuffel, D R Betts, M Dettling, R Schaub, B W Schäfer and F K Niggli

Leukemia 18: 1624-1629; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403462

Minimal Residual Disease in ALL

Analysis of minimal residual disease in childhood acute lymphoblastic leukemia: comparison between RQ-PCR analysis of Ig/TcR gene rearrangements and multicolor flow cytometric immunophenotyping FREE

M Malec, V H J van der Velden, E Björklund, J M Wijkhuijs, S Söderhäll, J Mazur, M Björkholm and A Porwit-MacDonald

Leukemia 18: 1630-1636; advance online publication, August 5, 2004; doi:10.1038/sj.leu.2403444

Minimal Residual Disease in CLL

Comparative analysis of minimal residual disease detection using four-color flow cytometry, consensus IgH-PCR, and quantitative IgH PCR in CLL after allogeneic and autologous stem cell transplantation FREE

S Böttcher, M Ritgen, C Pott, M Brüggemann, T Raff, S Stilgenbauer, H Döhner, P Dreger and M Kneba

Leukemia 18: 1637-1645; advance online publication, September 2, 2004; doi:10.1038/sj.leu.2403478

APL Biology

The expression of immediate early gene X-1 (IEX-1) is differentially induced by retinoic acids in NB4 and KG1 cells: possible implication in the distinct phenotype of retinoic acid-responsive and -resistant leukemic cells FREE

A Arlt, J Minkenberg, B Kocs, M Gros zligmann, M-L Kruse, U R Fölsch and H Schäfer

Leukemia 18: 1646-1655; advance online publication, August 12, 2004; doi:10.1038/sj.leu.2403481

Dendritic Cells in CML

Defective blood dendritic cells in chronic myeloid leukemia correlate with high plasmatic VEGF and are not normalized by imatinib mesylate FREE

N Boissel, P Rousselot, E Raffoux, J-M Cayuela, O Maarek, D Charron, L Degos, H Dombret, A Toubert and D Rea

Leukemia 18: 1656-1661; advance online publication, September 2, 2004; doi:10.1038/sj.leu.2403474

Apoptosis

Interleukin-1beta maintains an apoptosis-resistant phenotype in the blast cells of acute myeloid leukaemia via multiple pathways FREE

J Turzanski, M Grundy, N H Russell and M Pallis

Leukemia 18: 1662-1670; advance online publication, August 12, 2004; doi:10.1038/sj.leu.2403457

Differential involvement of Bax and Bak in TRAIL-mediated apoptosis of leukemic T cells FREE

J Han, L A Goldstein, B R Gastman, A Rabinovitz, G-Q Wang, B Fang and H Rabinowich

Leukemia 18: 1671-1680; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403496

BMT

Mixed hematopoietic chimerism at day 90 following allogenic myeloablative stem cell transplantation is a predictor of relapse and survival FREE

R Lamba, E Abella, D Kukuruga, J Klein, S Savasan, M H Abidi, A Mohamed and E Peres

Leukemia 18: 1681-1686; advance online publication, August 19, 2004; doi:10.1038/sj.leu.2403468

Myeloma

DNA methylation changes in multiple myeloma FREE

O Galm, S Wilop, J Reichelt, E Jost, G Gehbauer, J G Herman and R Osieka

Leukemia 18: 1687-1692; advance online publication, August 19, 2004; doi:10.1038/sj.leu.2403434

Lymphomas

Establishment of a novel anaplastic large-cell lymphoma-cell line (COST) from a 'small-cell variant' of ALCL FREE

L Lamant, E Espinos, M Duplantier, N Dastugue, A Robert, M Allouche, J Ragab, P Brousset, C Villalva, R D Gascoyne, T Al Saati and G Delsol

Leukemia 18: 1693-1698; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403464

Antitumor effects of bortezomib (PS-341) on primary effusion lymphomas FREE

J An, Y Sun, M Fisher and M B Rettig

Leukemia 18: 1699-1704; advance online publication, September 2, 2004; doi:10.1038/sj.leu.2403460

Variant t(2;11)(p11;q13) associated with the IgK-CCND1 rearrangement is a recurrent translocation in leukemic small-cell B-non-Hodgkin lymphoma FREE

I Wlodarska, P Meeus, M Stul, L Thienpont, E Wouters, L Marcelis, H Demuynck, J-L Rummens, V Madoe and A Hagemeijer

Leukemia 18: 1705-1710; advance online publication, August 12, 2004; doi:10.1038/sj.leu.2403459

Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas FREE

C Kelaidi, F Rollot, S Park, M Tulliez, B Christoforov, Y Calmus, P Podevin, D Bouscary, P Sogni, P Blanche and F Dreyfus

Leukemia 18: 1711-1716; advance online publication, July 29, 2004; doi:10.1038/sj.leu.2403443

A long-term follow-up of 33 patients with non-Hodgkin's lymphoma who received the BEAM high-dose intensification regimen with cytokine support only and no transplant FREE

J Ph Laporte, M Yeshurun, L Fouillard, M Labopin, C Cailliot, S Lesage, F Isnard, A Najman and N-C Gorin

Leukemia 18: 1717-1721; advance online publication, August 5, 2004; doi:10.1038/sj.leu.2403427

Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites FREE

B Streubel, I Simonitsch-Klupp, L Müllauer, A Lamprecht, D Huber, R Siebert, M Stolte, F Trautinger, J Lukas, A Püspök, M Formanek, T Assanasen, H-K Müller-Hermelink, L Cerroni, M Raderer and A Chott

Leukemia 18: 1722-1726; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403501

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Correspondence

Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia after first relapse FREE

A von Stackelberg, K Seeger, G Henze and C Eckert

Leukemia 18: 1727-1728; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403475

Reply to the letter from von Stackelberg et al  FREE

E Coustan-Smith and D Campana

Leukemia 18: 1728-1729; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403477

VH gene analysis of hairy cell leukemia reveals a homogeneous mutation status and suggests its marginal zone B-cell origin FREE

V Vanhentenrijk, A Tierens, I Wlodarska, G Verhoef and C D Wolf-Peeters

Leukemia 18: 1729-1732; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403503

CD38 modifications in chronic lymphocytic leukemia: are they relevant? FREE

P Ghia, G Guida, C Scielzo, M Geuna and F Caligaris-Cappio

Leukemia 18: 1733-1735; advance online publication, September 2, 2004; doi:10.1038/sj.leu.2403504

Identification of a rare e6a2 BCR-ABL fusion gene during the disease progression of chronic myelomonocytic leukemia: a case report FREE

S Hayette, I Tigaud, X Thomas, M French, M C Perrin, F Nicolini, M Michallet and J P Magaud

Leukemia 18: 1735-1736; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403476

Altered splicing in hematological malignancies reveals a tissue-specific translational block of the Src-family tyrosine kinase fyn brain isoform expression FREE

C Picard, J Gabert, D Olive and Y Collette

Leukemia 18: 1737-1739; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403499

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Opinions and Ideas

Riddle: What do aplastic anemia, acute promyelocytic leukemia, and chronic myeloid leukemia have in common? FREE

R A Brodsky and R J Jones

Leukemia 18: 1740-1742; advance online publication, September 9, 2004; doi:10.1038/sj.leu.2403487

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Book Review

Clinical bone marrow and blood stem cell transplantation FREE

J-Y Cahn

Leukemia 18: 1743; doi:10.1038/sj.leu.2403437

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