TABLE OF CONTENTS
Volume 17, Issue 9 (September 2003)
Reviews |
Meeting Report and Mini Review |
Commentary and Mini-Reviews |
Molecular Targets for Therapy (MTT) |
Original Manuscripts |
Bio-Technical Methods (BTS) |
Spotlight Correspondence |
Correspondence
Spotlight
Molecular monitoring of response to imatinib (Glivec®) in CML patients pretreated with interferon alpha. Low levels of residual disease are associated with continuous remission FREE
P Paschka, M C Müller, K Merx, S Kreil, C Schoch, T Lahaye, A Weisser, A Petzold, H König, U Berger, H Gschaidmeier, R Hehlmann and A Hochhaus
Leukemia 17: 1687-1694; doi:10.1038/sj.leu.2403033
Phosphorylation of tyrosine 393 in the kinase domain of Bcr-Abl influences the sensitivity towards imatinib in vivo FREE
C Miething, C Mugler, R Grundler, J Hoepfl, R-Y Bai, C Peschel and J Duyster
Leukemia 17: 1695-1699; doi:10.1038/sj.leu.2403040
Serial minimal residual disease (MRD) analysis as a predictor of response duration in Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) during imatinib treatment FREE
U J Scheuring, H Pfeifer, B Wassmann, P Brück, B Gehrke, E K Petershofen, H Gschaidmeier, D Hoelzer and O G Ottmann
Leukemia 17: 1700-1706; doi:10.1038/sj.leu.2403062
Response to imatinib in patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia FREE
E Olavarria, O G Ottmann, M Deininger, R E Clark, G Bandini, J Byrne, J Lipton, A Vitek, M Michallet, W Siegert, A Ullmann, B Wassmann, D Niederwieser and T Fischer for the Chronic Leukaemia Working Party of the European Group of Bone and Marrow Transplantation (EBMT)
Leukemia 17: 1707-1712; doi:10.1038/sj.leu.2403068
Imatinib inhibits the in vitro development of the monocyte/macrophage lineage from normal human bone marrow progenitors FREE
A L Dewar, R M Domaschenz, K V Doherty, T P Hughes and A B Lyons
Leukemia 17: 1713-1721; doi:10.1038/sj.leu.2403071
Response to imatinib in patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia FREE
A Bacigalupo
Leukemia 17: 1722; doi:10.1038/sj.leu.2403072
Retinoid target genes in acute promyelocytic leukemia FREE
I Pitha-Rowe, W J Petty, S Kitareewan and E Dmitrovsky
Leukemia 17: 1723-1730; doi:10.1038/sj.leu.2403065
Reviews
Transforming growth factor-
signaling in normal and malignant hematopoiesis FREE
S-J Kim and J Letterio
Leukemia 17: 1731-1737; doi:10.1038/sj.leu.2403069
FLT3: ITDoes matter in leukemia FREE
M Levis and D Small
Leukemia 17: 1738-1752; doi:10.1038/sj.leu.2403099
Meeting Report and Mini Review
Dendritic cells: interfaces with immunobiology and medicine. A report from the Keystone Symposia Meeting held in Keystone, 3–8 March 2003 FREE
M Mohty and B Gaugler
Leukemia 17: 1753-1758; doi:10.1038/sj.leu.2403049
Commentary and Mini-Reviews
Small-molecule inhibitors of signal transduction pathways in leukemia therapeutics: how to assess selectivity for malignant signals FREE
M K White
Leukemia 17: 1759-1761; doi:10.1038/sj.leu.2403053
Gene silencing of the p15/INK4B cell-cycle inhibitor by hypermethylation: an early or later epigenetic alteration in myelodysplastic syndromes? FREE
M Lübbert
Leukemia 17: 1762-1764; doi:10.1038/sj.leu.2403045
Molecular Targets for Therapy (MTT)
Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation FREE
J G Shelton, P W Moye, L S Steelman, W L Blalock, J T Lee, R A Franklin, M McMahon and J A McCubrey
Leukemia 17: 1765-1782; doi:10.1038/sj.leu.2403052
Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts FREE
P Lunghi, A Tabilio, P P Dall'Aglio, E Ridolo, C Carlo-Stella, P G Pelicci and A Bonati
Leukemia 17: 1783-1793; doi:10.1038/sj.leu.2403032
A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells FREE
A M Martelli, P L Tazzari, G Tabellini, R Bortul, A M Billi, L Manzoli, A Ruggeri, R Conte and L Cocco
Leukemia 17: 1794-1805; doi:10.1038/sj.leu.2403044
Effects of the farnesyl transferase inhibitor R115777 on normal and leukemic hematopoiesis FREE
J L Liesveld, J E Lancet, K E Rosell, A Menon, C Lu, C McNair II, C N Abboud and J D Rosenblatt
Leukemia 17: 1806-1812; doi:10.1038/sj.leu.2403063
Original Manuscripts
Methylation of p15 INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia FREE
D H Christiansen, M K Andersen and J Pedersen-Bjergaard
Leukemia 17: 1813-1819; doi:10.1038/sj.leu.2403054
Chronic myeloid leukemia in the elderly: long-term results from randomized trials with interferon 
FREE
U Berger, G Engelich, O Maywald, M Pfirrmann, A Hochhaus, A Reiter, G Metzgeroth, U Gnad, J Hasford, B Heinze, H Heimpel, D K Hossfeld, H-J Kolb, H Löffler, H Pralle, W Queisser and R Hehlmann and the German CML-Study Group
Leukemia 17: 1820-1826; doi:10.1038/sj.leu.2403042
No benefit from adding GM-CSF to induction chemotherapy in transforming myelodysplastic syndromes: better outcome in patients with less proliferative disease FREE
R Hast, E Hellström-Lindberg, L Ohm, M Björkholm, F Celsing, I-M Dahl, I Dybedal, G Gahrton, G Lindberg, R Lerner, O Linder, E Löfvenberg, H Nilsson-Ehle, C Paul, J Samuelsson, J-M Tangen, U Tidefelt, I Turesson, A Wahlin, J Wallvik, I Winquist, G Öberg and P Bernell
Leukemia 17: 1827-1833; doi:10.1038/sj.leu.2403035
Age-related patterns of immunoglobulin and T-cell receptor gene rearrangements in precursor-B-ALL: implications for detection of minimal residual disease FREE
V H J van der Velden, T Szczepanski, J M Wijkhuijs, P G Hart, P G Hoogeveen, W C J Hop, E R van Wering and J J M van Dongen
Leukemia 17: 1834-1844; doi:10.1038/sj.leu.2403038
Concurrent methylation of multiple genes in childhood ALL: Correlation with phenotype and molecular subgroup FREE
M I Gutierrez, A K Siraj, M Bhargava, U Ozbek, S Banavali, M A Chaudhary, H El Solh and K Bhatia
Leukemia 17: 1845-1850; doi:10.1038/sj.leu.2403060
t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH) FREE
R Berger, N Dastugue, M Busson, J van den Akker, C Pérot, P Ballerini, A Hagemeijer, L Michaux, C Charrin, M P Pages, F Mugneret, J Andrieux, P Talmant, C Hélias, L Mauvieux, M Lafage-Pochitaloff, M-J Mozziconacci, P Cornillet-Lefebvre, I Radford, V Asnafi, C Bilhou-Nabera, F Nguyen Khac, C Léonard, F Speleman, B Poppe, C Bastard, S Taviaux, B Quilichini, C Herens, M-J Grégoire, H Cavé and O A Bernard on behalf of the Groupe Français de Cytogénétique Hématologique (GFCH)
Leukemia 17: 1851-1857; doi:10.1038/sj.leu.2403061
Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity FREE
B-W Gu, Q Wang, J-M Wang, Y-Q Xue, J Fang, K F Wong, B Chen, Z-Z Shi, J-Y Shi, X-T Bai, D-H Wu, Z Chen and S-J Chen
Leukemia 17: 1858-1864; doi:10.1038/sj.leu.2403036
Lymphocyte recovery after allogeneic bone marrow transplantation predicts risk of relapse in acute lymphoblastic leukemia FREE
S Kumar, M G Chen, D A Gastineau, M A Gertz, D J Inwards, M Q Lacy, A Tefferi and M R Litzow
Leukemia 17: 1865-1870; doi:10.1038/sj.leu.2403055
Tolerance induction by costimulator blockade in 100 cGy treated hosts with varying degrees of genetic disparity FREE
M Abedi, D Greer, J F Lambert, G A Colvin, M S Dooner, C I McAuliffe, D Demers, B E Moore and P J Quesenberry
Leukemia 17: 1871-1879; doi:10.1038/sj.leu.2403070
High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma FREE
T C Islam, A C Asplund, J M Lindvall, L Nygren, J Liden, E Kimby, B Christensson, C I E Smith and B Sander
Leukemia 17: 1880-1890; doi:10.1038/sj.leu.2403057
Bio-Technical Methods (BTS)
Novel potential ALL low-risk markers revealed by gene expression profiling with new high-throughput SSH–CCS–PCR FREE
J Qiu, P Gunaratne, L E Peterson, D Khurana, N Walsham, H Loulseged, R J Karni, E Roussel, R A Gibbs, J F Margolin and M C Gingras
Leukemia 17: 1891-1900; doi:10.1038/sj.leu.2403073
Spotlight Correspondence
Myelodysplastic features developing in Philadephia-negative cells during imatinib mesylate therapy for CML: report of a new case FREE
M J Mozziconacci, S Caillères, C Maurice, N Vey, D Sainty, D Blaise and M Lafage-Pochitaloff
Leukemia 17: 1901-1902; doi:10.1038/sj.leu.2403037
Correspondence
Expression levels of DNA methyltransferase genes do not correlate with p15 INK4B gene methylation in myelodysplastic syndromes FREE
E Aoki, H Ohashi, T Uchida, T Murate, H Saito and T Kinoshita
Leukemia 17: 1903-1904; doi:10.1038/sj.leu.2403046
Environmental factors contributing to the development of childhood leukemia in children with Down's syndrome FREE
J M Mejía-Aranguré, A Fajardo-Gutiérrez, H Flores-Aguilar, M C Martínez-García, F Salamanca-Gómez, V Palma-Padilla, R Paredes-Aguilera, R Bernáldez-Ríos, A Ortiz-Fernández, A Martínez-Avalos and C Gorodezky
Leukemia 17: 1905-1907; doi:10.1038/sj.leu.2403047
Molecular identification of CBF-MYH11 fusion transcripts in an AML M4Eo patient in the absence of inv16 or other abnormality by cytogenetic and FISH analyses – a rare occurrence FREE
F Ravandi, S S Kadkol, J Ridgeway, A Bruno, C Dodge and V Lindgren
Leukemia 17: 1907-1910; doi:10.1038/sj.leu.2403056
Generation of immunostimulatory dendritic cells from the malignant clone in patients with juvenile myelomonocytic leukemia FREE
S Nabarro, A J Thrasher, H Kempski, P Amrolia and J Anderson
Leukemia 17: 1910-1912; doi:10.1038/sj.leu.2403059
Association of acute leukemia and autoimmune polyendocrine syndrome in two kindreds FREE
E Willems, H Valdes-Socin, D Betea, A Beckers and Y Beguin
Leukemia 17: 1912-1914; doi:10.1038/sj.leu.2403064
Thalidomide therapy induces response in relapsed mantle cell lymphoma FREE
G Damaj, F Lefrère, R Delarue, B Varet, R Furman and O Hermine
Leukemia 17: 1914-1915; doi:10.1038/sj.leu.2403058
AML with t(8;21) and trisomy 4: possible involvement of c-kit? FREE
S E Langabeer, A Beghini and L Larizza
Leukemia 17: 1915; doi:10.1038/sj.leu.2403066
Reply to SE Langabeer et al FREE
F Lorenzo V, K Nishii, E Usui, N Katayama and H Shiku
Leukemia 17: 1915-1916; doi:10.1038/sj.leu.2403067
Prolonged molecular remission after arsenic trioxide and all-trans retinoic acid for acute promyelocytic leukemia relapsed after allogeneic stem cell transplantation FREE
A Grigg, R Kimber and J Szer
Leukemia 17: 1916-1917; doi:10.1038/sj.leu.2403050
