TABLE OF CONTENTS
Volume 17, Issue 8 (August 2003)
Spotlight |
Commentary and Mini-Reviews |
Reviews |
Molecular Targets for Therapy (MTT) |
Original Manuscripts |
Correspondence
Leading Article
Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications FREE
J S Carew, Y Zhou, M Albitar, J D Carew, M J Keating and Peng Huang
Leukemia 17: 1437-1447; doi:10.1038/sj.leu.2403043
Spotlight
Prognostic factors for patients with chronic myeloid leukaemia in chronic phase treated with imatinib mesylate after failure of interferon alfa FREE
D Marin, S Marktel, M Bua, R M Szydlo, A Franceschino, I Nathan, N Foot, C Crawley, T Na Nakorn, E Olavarria, A Lennard, A Neylon, S G O'Brien, J M Goldman and J F Apperley
Leukemia 17: 1448-1453; doi:10.1038/sj.leu.2402996
Treatment of acute promyelocytic leukemia: strategy toward further increase of cure rate FREE
R Ohno, N Asou and K Ohnishi
Leukemia 17: 1454-1463; doi:10.1038/sj.leu.2403031
Commentary and Mini-Reviews
Skipping the two-step? Possible mechanisms of Epstein–Barr virus reactivation FREE
M J Cannon and R Rochford
Leukemia 17: 1464-1466; doi:10.1038/sj.leu.2403041
High stem cell dose in haemopoietic transplantation: is it always beneficial? FREE
A Urbano-Ispizua
Leukemia 17: 1467-1469; doi:10.1038/sj.leu.2402977
Reviews
Recent advances in the development of anticancer agents targeting cell death inhibitors in the Bcl-2 protein family FREE
S Shangary and D E Johnson
Leukemia 17: 1470-1481; doi:10.1038/sj.leu.2403029
Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia FREE
M A Morgan, A Ganser and C W M Reuter
Leukemia 17: 1482-1498; doi:10.1038/sj.leu.2403024
Opportunities for Trisenox® (arsenic trioxide) in the treatment of myelodysplastic syndromes FREE
A List, M Beran, J DiPersio, J Slack, N Vey, C S Rosenfeld and P Greenberg
Leukemia 17: 1499-1507; doi:10.1038/sj.leu.2403021
Molecular Targets for Therapy (MTT)
Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors FREE
M A Morgan, J Wegner, E Aydilek, A Ganser and C W M Reuter
Leukemia 17: 1508-1520; doi:10.1038/sj.leu.2403022
Original Manuscripts
Risk-adapted postremission therapy in acute myeloid leukemia: results of the german multicenter AML HD93 treatment trial FREE
R F Schlenk, A Benner, F Hartmann, F del Valle, C Weber, H Pralle, JTh Fischer, U Gunzer, A Pezzutto, W Weber, W Grimminger, J Prei
, M Hensel, S Fröhling, K Döhner, R Haas and H Döhner for the AML Study Group Ulm (AMLSG ULM)
Leukemia 17: 1521-1528; doi:10.1038/sj.leu.2403009
Therapy
Randomized comparison of interferon 
and hydroxyurea with hydroxyurea monotherapy in chronic myeloid leukemia (CML-study II): prolongation of survival by the combination of interferon and hydroxyurea FREE
R Hehlmann, U Berger, M Pfirrmann, A Hochhaus, G Metzgeroth, O Maywald, J Hasford, A Reiter, D K Hossfeld, H-J Kolb, H Löffler, H Pralle, W Queier, M Griesshammer, C Nerl, R Kuse, A Tobler, H Eimermacher, A Tichelli, C Aul, M Wilhelm, J T Fischer, M Perker, C Scheid, M Schenk, J Wei, C R Meier, S Kremers, L Labedzki, T Schmeiser, H-P Lohrmann and H Heimpel and the German CML-Study Group
Leukemia 17: 1529-1537; doi:10.1038/sj.leu.2403006
The percentage of myeloperoxidase-positive blast cells is a strong independent prognostic factor in acute myeloid leukemia, even in the patients with normal karyotype FREE
T Matsuo, K Kuriyama, Y Miyazaki, S Yoshida, M Tomonaga, N Emi, T Kobayashi, S Miyawaki, T Matsushima, K Shinagawa, S Honda and R Ohno for the Japan Adult Leukemia Study Group
Leukemia 17: 1538-1543; doi:10.1038/sj.leu.2403010
Low expression of the myeloid differentiation antigen CD65s, a feature of poorly differentiated AML in older adults: study of 711 patients enrolled in ECOG trials FREE
E Paietta, D Neuberg, J M Bennett, G Dewald, J M Rowe, P A Cassileth, L Cripe, M S Tallman and P H Wiernik and the Eastern Cooperative Oncology Group
Leukemia 17: 1544-1550; doi:10.1038/sj.leu.2402999
Childhood ALL
Expression of heat-shock protein 90 in glucocorticoid-sensitive and -resistant childhood acute lymphoblastic leukaemia FREE
M Lauten, C Beger, K Gerdes, G Asgedom, C Kardinal, K Welte and M Schrappe
Leukemia 17: 1551-1556; doi:10.1038/sj.leu.2403027
Computational analysis of flow-cytometry antigen expression profiles in childhood acute lymphoblastic leukemia: an MLL/AF4 identification FREE
L De Zen, S Bicciato, G te Kronnie and G Basso
Leukemia 17: 1557-1565; doi:10.1038/sj.leu.2403013
Minimal residual disease detection in childhood precursor–B-cell acute lymphoblastic leukemia: relation to other risk factors. A Children's Oncology Group study FREE
M J Borowitz, D J Pullen, J J Shuster, D Viswanatha, K Montgomery, C L Willman and B Camitta
Leukemia 17: 1566-1572; doi:10.1038/sj.leu.2403001
Clonality profile in relapsed precursor-B-ALL children by GeneScan and sequencing analyses. Consequences on minimal residual disease monitoring FREE
G Germano, L del Giudice, S Palatron, E Giarin, G Cazzaniga, A Biondi and G Basso
Leukemia 17: 1573-1582; doi:10.1038/sj.leu.2403008
Evaluation of immunologic crossreaction of antiasparaginase antibodies in acute lymphoblastic leukemia (ALL) and lymphoma patients FREE
B Wang, M V Relling, M C Storm, M H Woo, R Ribeiro, C-H Pui and L J Hak
Leukemia 17: 1583-1588; doi:10.1038/sj.leu.2403011
Adult ALL
Expression of the human homologue of rat NG2 in adult acute lymphoblastic leukemia: close association with MLL rearrangement and a CD10-/CD24-/CD65s+/CD15+ B-cell phenotype FREE
S Schwartz, H Rieder, B Schläger, T Burmeister, L Fischer and E Thiel
Leukemia 17: 1589-1595; doi:10.1038/sj.leu.2402989
Risk assessment in adult acute lymphoblastic leukaemia before early haemopoietic stem cell transplantation with a geno-identical donor: an easy clinical prognostic score to identify patients who benefit most from allogeneic haemopoietic stem cell transplantation FREE
N-C Gorin, M Labopin, E Polge, C Cordonnier, J P Jouet, M Michallet, D Blaise, J Reiffers, B Rio, N Milpied and F Frassoni on behalf of the Acute Leukaemia Working Party of the European Cooperative Group for Blood and Marrow Transplantation (EBMT)
Leukemia 17: 1596-1599; doi:10.1038/sj.leu.2403030
Myelodysplastic syndrome after acute promyelocytic leukemia: the European APL group experience FREE
I Lobe, F Rigal-Huguet, A Vekhoff, B Desablens, D Bordessoule, C Mounier, A Ferrant, M Sanz, M Fey, C Chomienne, S Chevret, L Degos and P Fenaux for the European APL group
Leukemia 17: 1600-1604; doi:10.1038/sj.leu.2403034
Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B FREE
R S Boyd, P J Adam, S Patel, J A Loader, J Berry, N T Redpath, H R Poyser, G C Fletcher, N A Burgess, A C Stamps, L Hudson, P Smith, M Griffiths, T G Willis, E L Karran, D G Oscier, D Catovsky, J A Terrett and M J S Dyer
Leukemia 17: 1605-1612; doi:10.1038/sj.leu.2402993
Coculture and transplant of purified CD34+Lin- and CD34-Lin- cells reveals functional interaction between repopulating hematopoietic stem cells FREE
D A Hess, F N Karanu, K Levac, L Gallacher and M Bhatia
Leukemia 17: 1613-1625; doi:10.1038/sj.leu.2403028
The presence and longevity of peripherally expanded donor-derived TCR
+ mature T lymphocyte clones after allogeneic bone marrow transplantation for adult myeloid leukemias FREE
H Saitoh, M Hirokawa, N Fujishima, Y Ichikawa, Y Kawabata, I Miura, A B Miura, T Matsutani, R Suzuki and K Sawada
Leukemia 17: 1626-1635; doi:10.1038/sj.leu.2402994
Defibrotide reduces procoagulant activity and increases fibrinolytic properties of endothelial cells FREE
A Falanga, A Vignoli, M Marchetti and T Barbui
Leukemia 17: 1636-1642; doi:10.1038/sj.leu.2403004
Tumor outgrowth in peripheral blood mononuclear cell-injected SCID mice is not associated with early Epstein–Barr virus reactivation FREE
E Piovan, L Bonaldi, S Indraccolo, V Tosello, C Menin, F Comacchio, L Chieco-Bianchi and A Amadori
Leukemia 17: 1643-1649; doi:10.1038/sj.leu.2403005
Myeloma
Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma FREE
Y Hayami, S Iida, N Nakazawa, I Hanamura, M Kato, H Komatsu, I Miura, B J Dave, W G Sanger, B Lim, M Taniwaki and R Ueda
Leukemia 17: 1650-1657; doi:10.1038/sj.leu.2403026
Lymphoma
Treatment of relapsed B-cell non-Hodgkin's lymphoma with a combination of chimeric anti-CD20 monoclonal antibodies (rituximab) and G-CSF: final report on safety and efficacy FREE
L E van der Kolk, A J Grillo-López, J W Baars and M H J van Oers
Leukemia 17: 1658-1664; doi:10.1038/sj.leu.2402995
Correspondence
Fusion of AML1/Runx1 to Copine VIII, a novel member of the copine family, in an aggressive acute myelogenous leukemia with t(12;21) translocation FREE
H Ramsey, Do-E Zhang, K Richkind, A Burcoglu-O'Ral and R Hromas
Leukemia 17: 1665-1666; doi:10.1038/sj.leu.2403048
Cryptic rearrangement involving MLL and AF10 occurring in utero FREE
L K Jones, M J Neat, F W van Delft, M P Mitchell, M Adamaki, S J Stoneham, N Patel and V Saha
Leukemia 17: 1667-1669; doi:10.1038/sj.leu.2403039
Sequential combination of thalidomide and erythropoietin determines transfusion independence and disease control in idiopathic myelofibrosis previously insensitive to both drugs used as single agents FREE
G Visani, A Mele, M Malagola, A Isidori, C Finelli and P P Piccaluga
Leukemia 17: 1669-1670; doi:10.1038/sj.leu.2403017
Monitoring all-trans-retinoic acid-induced differentiation of human acute promyelocytic leukemia NB4 cells by Fourier-transform infrared spectroscopy FREE
M-J Liu, Z Wang, R-C Wu, S-Q Sun and Q-Y Wu
Leukemia 17: 1670-1674; doi:10.1038/sj.leu.2403019
Minimal residual disease in acute myeloid leukemia is predicted by P-glycoprotein activity but not by multidrug resistance protein activity at diagnosis FREE
M A van der Pol, N Feller, G J Ossenkoppele, G W D Weijers, A H Westra, A van Stijn, H J Broxterman and G J Schuurhuis
Leukemia 17: 1674-1677; doi:10.1038/sj.leu.2403025
Absence of somatic mutations within the Runt domain of AML2/RUNX3 in acute myeloid leukaemia FREE
F Otto, M Stock, M Fliegauf, P Fenaux, C Preudhomme and M Lübbert
Leukemia 17: 1677-1678; doi:10.1038/sj.leu.2403007
SOCS-1 gene methylation is frequent but does not appear to have prognostic value in patients with multiple myeloma FREE
S Depil, A Saudemont and B Quesnel
Leukemia 17: 1678-1679; doi:10.1038/sj.leu.2403012
Amplification of band q22 of chromosome 21, including AML1, in older children with acute lymphoblastic leukemia: an emerging molecular cytogenetic subgroup FREE
J Soulier, L Trakhtenbrot, V Najfeld, J M Lipton, S Mathew, H Avet-Loiseau, M De Braekeleer, S Salem, A Baruchel, S C Raimondi and S D Raynaud
Leukemia 17: 1679-1682; doi:10.1038/sj.leu.2403000
Classification of mature T-cell leukemias FREE
E Matutes and D Catovsky
Leukemia 17: 1682-1683; doi:10.1038/sj.leu.2403003
Reply to the letter from Drs Matutes and Catovsky FREE
S J Kussick, B L Wood and D E Sabath
Leukemia 17: 1683; doi:10.1038/sj.leu.2403002
Identification of CD14 as a predictor for leukemic dendritic cell differentiation in acute myeloid leukemia FREE
I Houtenbos, T M Westers, G J Ossenkoppele and A A van de Loosdrecht
Leukemia 17: 1683-1684; doi:10.1038/sj.leu.2403014
Reply to van de Loosdrecht et al FREE
M Mohty, D Olive and B Gaugler
Leukemia 17: 1684; doi:10.1038/sj.leu.2403015
