TABLE OF CONTENTS
Volume 17, Issue 3 (March 2003)
Keynote Addresses |
Review |
Original Manuscripts |
Debate Round Table |
Spotlight Correspondence |
Correspondence |
Abstracts
Spotlight
Demonstration of Philadelphia chromosome negative abnormal clones in patients with chronic myelogenous leukemia during major cytogenetic responses induced by imatinib mesylate FREE
M E O'Dwyer, K M Gatter, M Loriaux, B J Druker, S B Olson, R E Magenis, H Lawce, M J Mauro, R T Maziarz and R M Braziel
Leukemia 17: 481-487; doi:10.1038/sj.leu.2402848
Keynote Addresses
Is modulation of multidrug resistance a viable strategy for acute myeloid leukemia? FREE
R A Larson
Leukemia 17: 488-491; doi:10.1038/sj.leu.2402809
New targets for therapy in acute myeloid leukemia FREE
F R Appelbaum
Leukemia 17: 492-495; doi:10.1038/sj.leu.2402810
Induction and postremission therapy: new agents FREE
R M Stone
Leukemia 17: 496-498; doi:10.1038/sj.leu.2402864
Review
Elitek™–rasburicase: an effective means to prevent and treat hyperuricemia associated with tumor lysis syndrome, a Meeting Report, Dallas, Texas, January 2002 FREE
P M Navolanic, C-H Pui, R A Larson, M R Bishop, T E Pearce, M S Cairo, S C Goldman, S C Jeha, C B Shanholtz, J P Leonard and J A McCubrey
Leukemia 17: 499-514; doi:10.1038/sj.leu.2402847
Original Manuscripts
Classification of Acute Myeloid Leukemias
Immunological classification of acute myeloblastic leukemias: relevance to patient outcome FREE
R O Casasnovas, F K Slimane, R Garand, G C Faure, L Campos, V Deneys, M Bernier, A Falkenrodt, G Lecalvez, M Maynadié and M C Béné
Leukemia 17: 515-527; doi:10.1038/sj.leu.2402821
Acute Lymphoblastic Leukemia
Deletions on der(9) chromosome in adult Ph-positive acute lymphoblastic leukemia occur with a frequency similar to that observed in chronic myeloid leukemia FREE
G Specchia, F Albano, L Anelli, C T Storlazzi, A Zagaria, M Mancini, A Cuneo, F Pane, R Foà, F Manolelli, V Liso and M Rocchi
Leukemia 17: 528-531; doi:10.1038/sj.leu.2402829
Modification of topoisomerase genes copy number in newly diagnosed childhood acute lymphoblastic leukemia FREE
E Guérin, N Entz-Werlé, D Eyer, E Pencreac'h, A Schneider, A Falkenrodt, F Uettwiller, A Babin, A-C Voegeli, M Lessard, M-P Gaub, P Lutz and P Oudet
Leukemia 17: 532-540; doi:10.1038/sj.leu.2402774
Urolithiasis in pediatric patients with acute lymphoblastic leukemia FREE
S C Howard, S D Kaplan, B I Razzouk, G K Rivera, J T Sandlund, R C Ribeiro, J E Rubnitz, A J Gajjar, W Ke, M L Hancock, J P Skoch, S Roy III, M Hudson and C-H Pui
Leukemia 17: 541-546; doi:10.1038/sj.leu.2402852
Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases FREE
L Harewood, H Robinson, R Harris, M Jabbar Al-Obaidi, G R Jalali, M Martineau, A V Moorman, N Sumption, S Richards, C Mitchell and C J Harrison on behalf of the Medical Research Council Childhood and Adult Leukaemia Working Parties
Leukemia 17: 547-553; doi:10.1038/sj.leu.2402849
Chronic Myeloid Leukemia
A phase II study of 
-interferon and oral arabinosyl cytosine (YNK01) in chronic myeloid leukemia FREE
G Rosti, F Bonifazi, E Trabacchi, A de Vivo, S Bassi, G Martinelli, N Testoni, D Russo and M Baccarani for the Italian Cooperative Study Group on Chronic Myeloid Leukemia
Leukemia 17: 554-559; doi:10.1038/sj.leu.2402850
Apoptosis
Telomerase inhibition enhances apoptosis in human acute leukemia cells: possibility of antitelomerase therapy FREE
A Nakajima, T Tauchi, G Sashida, M Sumi, K Abe, K Yamamoto, J H Ohyashiki and K Ohyashiki
Leukemia 17: 560-567; doi:10.1038/sj.leu.2402825
Fibrates and medroxyprogesterone acetate induce apoptosis of primary Burkitt's lymphoma cells and cell lines: potential for applying old drugs to a new disease FREE
S L Fenton, Q T Luong, A Sarafeim, K J W Mustard, J Pound, J C Desmond, J Gordon, M T Drayson and C M Bunce
Leukemia 17: 568-575; doi:10.1038/sj.leu.2402843
High susceptibility of human leukemic cells to Fas-induced apoptosis is restricted to G1 phase of the cell cycle and can be increased by interferon treatment FREE
I Jedema, R M Y Barge, R Willemze and J H F Falkenburg
Leukemia 17: 576-584; doi:10.1038/sj.leu.2402844
Burkitt's Lymphoma
Prospective analysis of minimal bone marrow infiltration in pediatric Burkitt's lymphomas by long-distance polymerase chain reaction for t(8;14)(q24;q32) FREE
L Mussolin, K Basso, M Pillon, E S d'Amore, A Lombardi, L Luzzatto, L Zanesco and A Rosolen
Leukemia 17: 585-589; doi:10.1038/sj.leu.2402828
Molecular Targets for Therapy (MTT)
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy FREE
F Chang, J T Lee, P M Navolanic, L S Steelman, J G Shelton, W L Blalock, R A Franklin and J A McCubrey
Leukemia 17: 590-603; doi:10.1038/sj.leu.2402824
Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity FREE
Z Zhu, K Hattori, H Zhang, X Jimenez, D L Ludwig, S Dias, P Kussie, H Koo, H J Kim, D Lu, M Liu, R Tejada, M Friedrich, P Bohlen, L Witte and S Rafii
Leukemia 17: 604-611; doi:10.1038/sj.leu.2402831
Debate Round Table
Chimerism testing after allogeneic stem cell transplantation: importance of timing and optimal technique for testing in different clinical–biological situations FREE
T Lion and N Muller-Bérat
Leukemia 17: 612; doi:10.1038/sj.leu.2402855
Serial quantification of lymphoid and myeloid mixed chimerism using multiplex PCR amplification of short tandem repeat-markers predicts graft rejection and relapse, respectively, after allogeneic transplantation of CD34+ selected cells from peripheral blood FREE
F Fernández-Avilés, A Urbano-Ispizua, M Aymerich, D Colomer, M Rovira, C Martinez, E Nadal, C Talarn, E Carreras and E Montserrat
Leukemia 17: 613-620; doi:10.1038/sj.leu.2402854
Quantification of donor and recipient hemopoietic cells by real-time PCR of single nucleotide polymorphisms FREE
F Maas, N Schaap, S Kolen, A Zoetbrood, I Buño, H Dolstra, T de Witte, A Schattenberg and E van de Wiel-van Kemenade
Leukemia 17: 621-629; doi:10.1038/sj.leu.2402856
Appendix: Method In Focus
Quantification of donor and recipient hemopoietic cells by real-time PCR of single nucleotide polymorphisms FREE
F Maas, N Schaap, S Kolen, A Zoetbrood, I Buño, H Dolstra, T de Witte, A Schattenberg and E van de Wiel-van Kemenade
Leukemia 17: 630-633; doi:10.1038/sj.leu.2402857
Spotlight Correspondence
Fatal myelodysplastic syndrome developing during therapy with imatinib mesylate and characterised by the emergence of complex Philadelphia negative clones FREE
Y L Chee, M A Vickers, D Stevenson, T L Holyoake and D J Culligan
Leukemia 17: 634-635; doi:10.1038/sj.leu.2402842
Correspondence
Prognostic impact of t(9;11) in childhood acute myeloid leukemia (AML) FREE
Luca Lo Nigro, Daria Bottino, Claudio Panarello, Cristina Morerio, Elena Mirabile, Anna Maria Rapella, Andrea Di Cataldo and Gino Schiliro
Leukemia 17: 636; doi:10.1038/sj.leu.2402846
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23) FREE
R B Lorsbach, J Moore, S Mathew, S C Raimondi, S T Mukatira and J R Downing
Leukemia 17: 637-641; doi:10.1038/sj.leu.2402834
VLA-4 affinity correlates with peripheral blood white cell count and DNA content in patients with precursor B-ALL FREE
A M Blenc, A Chiagev, L Sklar and R S Larson
Leukemia 17: 641-643; doi:10.1038/sj.leu.2402827
A discriminating screening is necessary to ascertain EVI1 expression by RT-PCR in malignant cells from the myeloid lineage without 3q26 rearrangement FREE
D Zoccola, L Legros, P Cassuto, J G Fuzibet, G Nucifora and S D Raynaud
Leukemia 17: 643-645; doi:10.1038/sj.leu.2402859
Expression of retinoic acid receptor–target genes during retinoic acid therapy for acute promyelocytic leukemia FREE
K Takitani, M Koh, C L Zhu, A Inoue, T Kuno, H Tanoue, M Miyake, T Nakagawa and H Tamai
Leukemia 17: 646-648; doi:10.1038/sj.leu.2402818
P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are induced by arsenic trioxide (As2O3), but are not the main mechanism of As2O3-resistance in acute promyelocytic leukemia cells FREE
A Takeshita, K Shinjo, K Naito, H Matsui, K Shigeno, S Nakamura, T Horii, M Maekawa, K Kitamura, T Naoe, K Ohnishi and R Ohno
Leukemia 17: 648-650; doi:10.1038/sj.leu.2402851
Molecular monitoring of acute myeloid leukemia associated with inv(16): threshold of CBF
/MYH11 transcript copy number above which relapse occurs and below which continuous Complete Remission is likely FREE
G Martinelli, S Buonamici, G Visani, M Malagola, P P Piccaluga, A Isidori, C Bosi, F Bonifazi, S Soverini, C Terragna, M Amabile, B Giannini and M Baccarani
Leukemia 17: 650-651; doi:10.1038/sj.leu.2402822
Reply to Martinelli et al FREE
A Guerrasio, C Pilatrino, D Cilloni, E Gottardi and G Saglio
Leukemia 17: 651-652; doi:10.1038/sj.leu.2402823
Expression of the two alternative [a] and [b] transcripts of CCND1 gene in cyclin D1-expressing B-malignancies: relevance for the pathogenesis FREE
G Roué, S Krieger, M Florent, M Roussel, F Duquesne, X Troussard, V Pichereau and B Sola
Leukemia 17: 652-655; doi:10.1038/sj.leu.2402817
Hairy cell leukemia and Lambert–Eaton myasthenic syndrome FREE
A Alexopoulou, S P Dourakis, O Louka, O Marinaki and T Kalmantis
Leukemia 17: 655-656; doi:10.1038/sj.leu.2402863
Abstracts
5th International Symposium on Leukemia and Lymphoma
12-15 March 2003
Vrije Universiteit, Amsterdam, The Netherlands FREE
K-M Debatin
Leukemia 17: 657-674; doi:10.1038/sj.leu.2402898
5th International Symposium on Leukemia and Lymphoma
12-15 March 2003
Vrije Universiteit, Amsterdam, The Netherlands FREE
E S Zakharova, A N Inshakov, A G Turkina, S S Kruglov, O A Dyagileva, G A Drouzhkova, I S Nemchenko, E Yu Chelysheva and A Yu Baryshnikov
Leukemia 17: 675-689; doi:10.1038/sj.leu.2402915
