FIGURE 1
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Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
F Chang, J T Lee, P M Navolanic, L S Steelman, J G Shelton, W L Blalock, R A Franklin and J A McCubrey
BACK TO ARTICLEFigure 1.
Activation of the PI3K/Akt pathway. Two mechanisms by which cytokine receptor activation can result in activation of the PI3K/Akt pathway are indicated. Note that significant activation of this pathway occurs in close proximity to the cell membrane. SH2: Src homology-2 domain; PH: pleckstrin homology domain.
