TABLE OF CONTENTS
Volume 17, Issue 12 (December 2003)
Review |
Commentary |
Keynote Address |
Spotlight |
Molecular Targets for Therapy (MTT) |
Original Manuscripts |
Bio-Technical Methods Section (BTS) |
Spotlight Correspondence |
Correspondence
Leading Articles
Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936 FREE
J J M van Dongen, A W Langerak, M Brüggemann, P A S Evans, M Hummel, F L Lavender, E Delabesse, F Davi, E Schuuring, R García-Sanz, J H J M van Krieken, J Droese, D González, C Bastard, H E White, M Spaargaren, M González, A Parreira, J L Smith, G J Morgan, M Kneba and E A Macintyre
Leukemia 17: 2257-2317; doi:10.1038/sj.leu.2403202
Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia – A Europe Against Cancer Program FREE
J Gabert, E Beillard, V H J van der Velden, W Bi, D Grimwade, N Pallisgaard, G Barbany, G Cazzaniga, J M Cayuela, H Cavé, F Pane, J L E Aerts, D De Micheli, X Thirion, V Pradel, M González, S Viehmann, M Malec, G Saglio and J J M van Dongen
Leukemia 17: 2318-2357; advance online publication, October 9, 2003; doi:10.1038/sj.leu.2403135
Review
Treatment by design in leukemia, a meeting report, Philadelphia, Pennsylvania, December 2002 FREE
R A Larson, G Q Daley, C A Schiffer, P Porcu, C-H Pui, J-P Marie, L S Steelman, F E Bertrand and J A McCubrey
Leukemia 17: 2358-2382; advance online publication, October 9, 2003; doi:10.1038/sj.leu.2403156
Commentary
A further milestone towards comprehensive standardization of quantitative RT-PCR protocols for leukemic fusion gene transcripts has been reached FREE
A Hochhaus
Leukemia 17: 2383-2384; advance online publication, October 9, 2003; doi:10.1038/sj.leu.2403137
Keynote Address
Unsolved issues in CLL biology and management FREE
G Dighiero
Leukemia 17: 2385-2391; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403154
Spotlight
Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon 
/ara-C FREE
M C Müller, N Gattermann, T Lahaye, M W N Deininger, A Berndt, S Fruehauf, A Neubauer, T Fischer, D K Hossfeld, F Schneller, S W Krause, C Nerl, H G Sayer, O G Ottmann, C Waller, W Aulitzky, P le Coutre, M Freund, K Merx, P Paschka, H König, S Kreil, U Berger, H Gschaidmeier, R Hehlmann and A Hochhaus
Leukemia 17: 2392-2400; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403157
Imatinib produces significantly superior molecular responses compared to interferon alfa plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase FREE
S Branford, Z Rudzki, A Harper, A Grigg, K Taylor, S Durrant, C Arthur, P Browett, A P Schwarer, D Ma, J F Seymour, K Bradstock, D Joske, K Lynch, I Gathmann and T P Hughes
Leukemia 17: 2401-2409; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403158
Molecular Targets for Therapy (MTT)
Telomerase is limiting the growth of acute myeloid leukemia cells FREE
A Röth, S Vercauteren, H J Sutherland and P M Lansdorp
Leukemia 17: 2410-2417; advance online publication, October 9, 2003; doi:10.1038/sj.leu.2403177
Increased expression of fibroblast growth factor receptor 3 in CD34+ BCR-ABL+ cells from patients with chronic myeloid leukemia FREE
P Dvorak, D Dvorakova, M Doubek, J Faitova, J Pacholikova, A Hampl and J Mayer
Leukemia 17: 2418-2425; advance online publication, October 9, 2003; doi:10.1038/sj.leu.2403152
Original Manuscripts
B-CLL
ZAP-70 expression is a prognostic factor in chronic lymphocytic leukemia FREE
J Dürig, H Nückel, M Cremer, A Führer, K Halfmeyer, J Fandrey, T Möröy, L Klein-Hitpass and U Dührsen
Leukemia 17: 2426-2434; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403147
Flavopiridol downregulates the expression of both the inducible NO synthase and p27kip1 in malignant cells from B-cell chronic lymphocytic leukemia FREE
C Billard, C Kern, R Tang, F Ajchenbaum-Cymbalista and J-P Kolb
Leukemia 17: 2435-2443; advance online publication, September 18, 2003; doi:10.1038/sj.leu.2403139
CML
Marrow fibrosis, indicator of therapy failure in chronic myeloid leukemia – prospective long-term results from a randomized-controlled trial FREE
G Buesche, R Hehlmann, H Hecker, H Heimpel, B Heinze, A Schmeil, M Pfirrmann, G Gomez, A Tobler, H Herrmann, M Kappler, J Hasford, T Buhr, H-H Kreipe, A Georgii and the German CML Study Group
Leukemia 17: 2444-2453; advance online publication, October 16, 2003; doi:10.1038/sj.leu.2403172
B-Cell Ontogeny in t(4;11) Leukemia
B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression FREE
F E Bertrand, J D Spengeman, N Shah and T W LeBien
Leukemia 17: 2454-2459; advance online publication, October 16, 2003; doi:10.1038/sj.leu.2403178
MDS and Apoptosis
Expression of FLIPLong and FLIPShort in bone marrow mononuclear and CD34+ cells in patients with myelodysplastic syndrome: correlation with apoptosis FREE
M Benesch, U Platzbecker, J Ward, H J Deeg and W Leisenring
Leukemia 17: 2460-2466; advance online publication, October 16, 2003; doi:10.1038/sj.leu.2403180
Hairy Cell Leukemia
Synaptojanin 2 is recognized by HLA class II-restricted hairy cell leukemia-specific T cells FREE
E H A Spaenij-Dekking, J Van Delft, E Van der Meijden, H S Hiemstra, J H F Falkenburg, F Koning, J W Drijfhout and J C Kluin-Nelemans
Leukemia 17: 2467-2473; advance online publication, October 16, 2003; doi:10.1038/sj.leu.2403174
Minimal Residual Disease
Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) – a Europe against cancer program FREE
E Beillard, N Pallisgaard, V H J van der Velden, W Bi, R Dee, E van der Schoot, E Delabesse, E Macintyre, E Gottardi, G Saglio, F Watzinger, T Lion, J J M van Dongen, P Hokland and J Gabert
Leukemia 17: 2474-2486; advance online publication, October 9, 2003; doi:10.1038/sj.leu.2403136
Leukemogenomics
Somatic mitochondrial DNA mutations in adult-onset leukaemia FREE
L He, L Luo, S J Proctor, P G Middleton, E L Blakely, R W Taylor and D M Turnbull
Leukemia 17: 2487-2491; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403146
Leukemogenesis
Dual mutations in the AML1 and FLT3 genes are associated with leukemogenesis in acute myeloblastic leukemia of the M0 subtype FREE
N Matsuno, M Osato, N Yamashita, M Yanagida, T Nanri, T Fukushima, T Motoji, S Kusumoto, M Towatari, R Suzuki, T Naoe, K Nishii, K Shigesada, R Ohno, H Mitsuya, Y Ito and N Asou
Leukemia 17: 2492-2499; advance online publication, October 9, 2003; doi:10.1038/sj.leu.2403160
Lymphoma
Stimulation of non-Hodgkin's lymphoma via HVEM: an alternate and safe way to increase Fas-induced apoptosis and improve tumor immunogenicity FREE
R T Costello, F Mallet, B Barbarat, J-M Schiano de Colella, D Sainty, R W Sweet, A Truneh and D Olive
Leukemia 17: 2500-2507; advance online publication, October 16, 2003; doi:10.1038/sj.leu.2403175
Heterogeneous copy numbers of API2-MALT1 chimeric transcripts in mucosa-associated lymphoid tissue lymphoma FREE
M Suguro-Katayama, R Suzuki, Y Kasugai, T Nakamura, H Suzuki, Y Hosokawa, H Shiku, S Nakamura and M Seto
Leukemia 17: 2508-2512; advance online publication, October 16, 2003; doi:10.1038/sj.leu.2403179
Increased serum levels of interleukin-9 correlate to negative prognostic factors in Hodgkin's lymphoma FREE
M Fischer, M Bijman, D Molin, F Cormont, C Uyttenhove, J van Snick, C Sundström, G Enblad and G Nilsson
Leukemia 17: 2513-2516; advance online publication, October 9, 2003; doi:10.1038/sj.leu.2403123
Bio-Technical Methods Section (BTS)
Comparison between TaqMan and LightCycler technologies for quantification of minimal residual disease by using immunoglobulin and T-cell receptor genes consensus probes FREE
C Eckert, C A Scrideli, T Taube, S Songia, S Wellmann, M Manenti, K Seeger, A Biondi and G Cazzaniga
Leukemia 17: 2517-2524; advance online publication, October 9, 2003; doi:10.1038/sj.leu.2403103
Spotlight Correspondence
Autologous peripheral blood stem cell transplantation of stem cells harvested in imatinib-induced complete cytogenetic remission: an example of in vivo purging in CML FREE
P le Coutre, K A Kreuzer, G Massenkeil, G Baskaynak, P Zschieschang, I Genvresse, J Lupberger, M Mapara, B Dörken and R Arnold
Leukemia 17: 2525-2526; advance online publication, October 9, 2003; doi:10.1038/sj.leu.2403170
Correspondence
Influence of stochastics on quantitative PCR in the detection of minimal residual disease FREE
D Rawer, A Borkhardt, M Wilda, S Kropf and J Kreuder
Leukemia 17: 2527-2528; doi:10.1038/sj.leu.2403191
Response to Influence of stochastics on quantitative PCR in the detection of minimal residual disease by Rawer et al FREE
R Arlinghaus, H Lin, H-W Kim and J Q Guo
Leukemia 17: 2528-2529; doi:10.1038/sj.leu.2403192
Reply to Arlinghaus et al FREE
D Rawer, A Borkhardt, M Wilda, S Kropf and J Kreuder
Leukemia 17: 2529-2530; doi:10.1038/sj.leu.2403193
Reply to Rawer et al (second letter) FREE
R Arlinghaus, H Lin, J Q Guo, H-W Kim and S Ke
Leukemia 17: 2530; doi:10.1038/sj.leu.2403194
Reply to Arlinghaus et al (second letter) FREE
D Rawer, A Borkhardt, M Wilda, S Kropf and J Kreuder
Leukemia 17: 2531; doi:10.1038/sj.leu.2403195
Reply to Hasle et al FREE
A Gassas, M H Freedman, K Mandel and Y Dror
Leukemia 17: 2531-2532; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403165
Reply to Gassas et al FREE
H Hasle, C M Niemeyer, J M Chessells, I Baumann, J M Bennett, G Kerndrup and D R Head
Leukemia 17: 2532; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403166
Disruption of INK4/CDK/Rb cell cycle pathway by gene hypermethylation in multiple myeloma and MGUS FREE
C S Chim, T K Fung and R Liang
Leukemia 17: 2533-2535; advance online publication, September 11, 2003; doi:10.1038/sj.leu.2403133
High incidence of trisomies 1q, 9q, and 11q in multiple myeloma: results from a comprehensive molecular cytogenetic analysis FREE
P Liebisch, C Wendl, A Wellmann, A Kröber, G Schilling, H Goldschmidt, H Einsele, C Straka, M Bentz, S Stilgenbauer and H Döhner
Leukemia 17: 2535-2537; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403153
EBV-related lymphoproliferative disorders in immunocompetent patients FREE
M Oosterveld, W J Lesterhuis, M MacKenzie and J H J M van Krieken
Leukemia 17: 2537-2538; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403155
Unrelated umbilical cord blood stem cell transplant after failure of haploidentical or matched unrelated donor hematopoietic stem cell transplant FREE
O Khorshid, E de Meis, T Martin, R B Jones, E J Shpall, Y Nieto, I Khouri, M Shahjahan, J Gajewski, S Giralt, R Champlin and M de Lima
Leukemia 17: 2538-2540; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403163
GST polymorphisms and occurrence of second neoplasms after treatment of childhood leukemia FREE
J Jazbec, R Aplenc, V Dolzan, M Debeljak and B Jereb
Leukemia 17: 2540-2542; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403164
Successful treatment of hyperuricemia with low doses of recombinant urate oxidase in four patients with hematologic malignancy and tumor lysis syndrome FREE
M Hummel, D Buchheidt, S Reiter, J Bergmann, R Hofheinz and R Hehlmann
Leukemia 17: 2542-2544; advance online publication, October 2, 2003; doi:10.1038/sj.leu.2403161
