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| June 2002, Volume 16, Number 6, Pages 973-984 |
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| Spotlight on Chronic Lymphocytic Leukemia |
| The configuration of the immunoglobulin genes in B cell chronic lymphocytic leukemia |
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| M J S Dyer1 and D G Oscier2 |
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1Department of Haematology, University of Leicester, Leicester, UK
2Department of Haematology, Royal Bournemouth Hospital, Bournemouth, UK
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Correspondence to: M J S Dyer, Department of Haematology, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, PO Box 65, Leicester, LE2 7LX, UK; Fax: 44-116-252-3274 |
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| Abstract |
| B cell chronic lymphocytic leukemia (CLL) lacks a consistent genetic abnormality. However, immunoglobulin VH gene segment mutation analysis has provided insights into the pathogenesis of these diseases and allowed the development of powerful prognostic markers. Immunoglobulin gene chromosomal translocations are rare in CLL and involve a distinct subset of genes including BCL3, BCL11A and CCND2. BCL2 translocations in CLL appear to arise via a different mechanism from comparable translocations seen in B cell non-Hodgkin lymphoma. Leukemia (2002) 16, 973-984. DOI: 10.1038/sj/leu/2402528 |
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| Keywords |
| chronic lymphocytic leukemia; immunoglobulin genes; VH mutations; BCL6 mutations; chromosomal translocations |
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| Received 27 November 2001; accepted 19 February 2002 |
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| June 2002, Volume 16, Number 6, Pages 973-984 |
| Table of contents Previous Abstract Next Full text PDF |
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