Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

High frequency of the 844ins68 cystathionine-β-synthase gene variant in Down syndrome children with acute myeloid leukemia

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Tsai MY, Bignell M, Schwichtenberg K, Hanson NQ . High prevalence of a mutation in the cystathionine β-synthase gene Am J Hum Genet 1996 59: 1262–1267

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Taub JW, Huang X, Matherly LH, Stout ML, Buck SA, Massey GV, Becton DL, Chang MN, Weinstein HJ, Ravindranath Y . Expression of chromosome 21-localized genes in acute myeloid leukemia: differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin Blood 1999 94: 1393–1400

    CAS  PubMed  Google Scholar 

  3. Taub JW . The relationship of chromosome 21 and acute leukemia in Down syndrome and non-Down syndrome children J Pediatr Hematol Oncol 2001 23: 175–178

    Article  CAS  Google Scholar 

  4. Barbaux S, Plomin R, Whitehead AS . Polymorphisms of genes controlling homocysteine/folate metabolism and cognitive function Neuroreport 2000 11: 1133–1136

    Article  CAS  Google Scholar 

  5. Tsai MY, Yang F, Bignell M, Aras O, Hanson NQ . Relationship between plasma homocysteine concentration, the 844ins68 variant of the cystathionine beta-synthase gene, and pyridoxal-5′-phosphate concentration Mol Genet Metab 1999 67: 352–356

    Article  CAS  Google Scholar 

  6. Silaste ML, Rantala M, Sämpi M, Alfthan G, Aro A, Kesäniemi YA . Polymorphisms of key enzymes in homocysteine metabolism affect diet responsiveness of plasma homocysteine in healthy women J Nutr 2001 131: 2643–2647

    Article  CAS  Google Scholar 

  7. James SJ, Pogribna M, Pogribny IP, Melnyk S, Hine RJ, Gibson JB, Yi P, Tafoya DL, Swenson DH, Wilson VL, Gaylor DW . Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome Am J Clin Nutr 1999 70: 495–501

    Article  CAS  Google Scholar 

  8. Hobbs CA, Sherman SL, Yi P, Hopkins SE, Torfs CP, Hine RJ, Pogribna M, Rozen R, James SJ . Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome Am J Hum Genet 2000 67: 623–630

    Article  CAS  Google Scholar 

Download references

Acknowledgements

Supported by grant (RO1 CA92308), from the National Cancer Institute, National Institutes of Health, Children's Research Center of Michigan, Art Gagnon Memorial Fund, BPCT Golf Charity, and Leukemia Research, Life, Inc. (Detroit, MI). JWT is a Scholar in Clinical Research of the Leukemia and Lymphoma Society.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ge, Y., Jensen, T., James, S. et al. High frequency of the 844ins68 cystathionine-β-synthase gene variant in Down syndrome children with acute myeloid leukemia. Leukemia 16, 2339–2341 (2002). https://doi.org/10.1038/sj.leu.2402705

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2402705

This article is cited by

Search

Quick links