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| November 2002, Volume 16, Number 11, Pages 2177-2184 |
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| Leading Article |
| Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities |
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| J Pedersen-Bjergaard, D H Christiansen, M K Andersen and F Skovby |
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Cytogenetic Laboratory, Section of Hematology/Oncology, Department of Clinical Genetics, Juliane Marie Center, University Hospital, Rigshospitalet, Copenhagen, Denmark
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Correspondence to: J Pedersen-Bjergaard, Section 4052, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark; Fax: +45 3545 2577 |
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| Abstract |
| New insights into causative factors for the development of myelodysplasia (MDS) and acute myeloid leukemia (AML), with associations to specific cytogenetic and genetic abnormalities have been obtained primarily from studies of patients with the therapy-related subsets of the two diseases. Current knowledge now makes it possible to distinguish between at least seven major genetic subgroups of MDS and AML, and has directed research towards more specific causative factors also for de novo MDS and AML. Leukemia (2002) 16, 2177-2184. doi:10.1038/sj.leu.2402764 |
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| Keywords |
| myelodysplasia; acute myeloid leukemia; therapy related leukemia; epidemiology; chromosome abnormalities; alkylating agents; topoisomerase II inhibitors |
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| Received 19 April 2002; accepted 26 July 2002 |
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| November 2002, Volume 16, Number 11, Pages 2177-2184 |
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