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| November 2002, Volume 16, Number 11, Pages 2197-2204 |
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| Review |
| Leukemic dendritic cells: potential for therapy and insights towards immune escape by leukemic blasts |
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| M Mohty1, D Olive1,2 and B Gaugler1,2 |
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1Laboratoire d'Immunologie des Tumeurs, Institut Paoli-Calmettes, Université de la Méditerranée, Marseille, France
2Institut National de la Santé et de la Recherche Médicale (INSERM) U119, Marseille, France
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Correspondence to: D Olive or B Gaugler, Immunologie des Tumeurs, Institut Paoli-Calmettes, 232 Bd Ste Marguerite, 13273 Marseille Cedex 09, France; Fax: +33 491 223610 |
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| Abstract |
| Dendritic cells (DCs) are a system of potent antigen-presenting cells (APCs) specialized to initiate primary immune responses. DCs are considered important elements in the induction of specific antitumor cytotoxic effectors. At present, because of potential therapeutic implications, the critical role of DCs in cancer patients is under intensive investigation. Interactions between DCs and acute myeloid leukemia cells represent an attractive model for the study of DC physiology. Moreover, DCs can be a valuable therapeutic tool for the adjuvant treatment of leukemic patients. However, DC subsets in vivo may also be affected by leukemogenesis and may contribute to the escape of leukemia from immune control. The aim of this review is to shed further light on this paradoxical picture where the line between immune tolerance and immune defense is narrow. Leukemia (2002) 16, 2197-2204. doi:10.1038/sj.leu.2402710 |
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| Keywords |
| leukemia; dendritic cells; immunotherapy |
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| Received 13 February 2002; accepted 30 May 2002 |
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| November 2002, Volume 16, Number 11, Pages 2197-2204 |
| Table of contents Previous Abstract Next Full text PDF |
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