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| Spotlight on Acute Promyelocytic Leukemia |
| Variations on a theme: the alternate translocations in APL |
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| R L Redner |
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Department of Medicine, University of Pittsburgh, and the University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
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Correspondence to: R L Redner, E1058 BST, 211 Lothrop St, University of Pittsburgh, Pittsburgh PA 15213, USA; Fax: 412 624 9624 |
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| Abstract |
| The t(15;17)(q22;q21) translocation is tightly linked to the APL phenotype, and the resultant PML-RAR fusion can be demonstrated in 98% of APL cases. Rare variant translocations have been reported, the majority of which on detailed analysis represent cryptic PML-RAR fusions. However, a handful of APL cases have been described with different genotypes. These include the t(11;17)(q23;q21) that produces the PLZF-RAR fusion, t(5;17)(q35;q21) that forms NPM-RAR, t(11;17)(q13;q21) that generates NUMA-RAR, and der(17) that creates STAT5b-RAR. In this review we will discuss these variant translocations, and discuss the insights that we have gained from their study. Leukemia (2002) 16, 1927-1932. doi:10.1038/sj.leu.2402720 |
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| Keywords |
| APL; PML-RAR; PLZF-RAR; NPM-RAR; NUMA-RAR; STAT5b-RAR |
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| Received 6 June 2002; accepted 21 June 2002 |
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| October 2002, Volume 16, Number 10, Pages 1927-1932 |
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