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NUP98 gene fusions in hematologic malignancies

Leukemia volume 15, pages 1689–1695 (2001)Cite this article

Abstract

Acute leukemia is associated with a wide spectrum of recurrent, non-random chromosomal translocations. Molecular analysis of the genes involved in these translocations has led to a better understanding of both the causes of chromosomal rearrangements as well as the mechanisms of leukemic transformation. Recently, a number of laboratories have cloned translocations involving the NUP98 gene on chromosome 11p15.5, from patients with acute myelogenous leukemia (AML), myelodysplastic syndrome (MDS), chronic myelogenous leukemia (CML), and T cell acute lymphoblastic leukemia (T-ALL). To date, at least eight different chromosomal rearrangements involving NUP98 have been identified. The resultant chimeric transcripts encode fusion proteins that juxtapose the N-terminal GLFG repeats of NUP98 to the C-terminus of the partner gene. Of note, several of these translocations have been found in patients with therapy-related acute myelogenous leukemia (t-AML) or myelodysplastic syndrome (t-MDS), suggesting that genotoxic chemotherapeutic agents may play an important role in generating chromosomal rearrangements involving NUP98.

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  1. Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA

    DH Lam

  2. Genetics Department, Division of Clinical Sciences, Medicine Branch, National Cancer Institute, Bethesda, MD, USA

    DH Lam & PD Aplan

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Lam, D., Aplan, P. NUP98 gene fusions in hematologic malignancies. Leukemia 15, 1689–1695 (2001). https://doi.org/10.1038/sj.leu.2402269

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