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December 1999, Volume 13, Number 12, Pages 1932-1942
Table of contents    Previous  Abstract  Next   Article  PDF
Review
Leukemogenesis by CBF oncoproteins
A D Friedman

Division of Pediatric Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Correspondence to: A D Friedman, Johns Hopkins Oncology Center, Rm 3-109, 600 N Wolfe Street, Baltimore, MD 21287, USA; Fax: 410-955-8897

Abstract

The AML1 and CBFbeta subunits of core binding factor (CBF) are involved in several chromosomal abnormalities frequently associated with acute leukemias. As a result, the CBFbeta-SMMHC, AML1-ETO and AML1-MDS1/EVI1 fusion proteins are expressed in subsets of acute myeloid leukemia, and TEL-AML1 is expressed in B-lineage acute lymphocytic leukemia. These CBF oncoproteins likely contribute to leukemogenesis in part by inhibiting endogenous CBF. As a result they are expected to inhibit differentiation and perhaps apoptosis. In addition, the domains unique to each fusion protein may also contribute to leukemogenesis via unique mechanisms.

Keywords

CBF; CBFbeta-SMMHC; AML1-ETO; TEL-AML1; AML1-MDS1/EVI1

Received 12 May 1999; accepted 10 August 1999
December 1999, Volume 13, Number 12, Pages 1932-1942
Table of contents    Previous  Abstract  Next   Article  PDF