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November 1999, Volume 13, Number 11, Pages 1646-1674
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Review
Chronic myeloid leukemia from basics to bedside
S F T Thijsen, G J Schuurhuis, J W van Oostveen and G J Ossenkoppele

Department of Hematology, Br 250, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands

Correspondence to: GJ Ossenkoppele, Fax: 31-20-4442601

Abstract

The discovery of the Philadelphia chromosome and its consistent involvement in chronic myeloid leukemia (CML) was the first time that a relationship between a cytogenetic abnormality and malignancy was demonstrated. This review will try to provide an insight into the molecular mechanisms underlying this disease and outline the therapeutical options for patients with CML.

Keywords

CML; BCR-ABL; signal transduction; purging; therapy; review

Received 9 March 1999; accepted 20 July 1999
November 1999, Volume 13, Number 11, Pages 1646-1674
Table of contents    Previous  Abstract  Next   Article  PDF