Welcome to Leukemia - celebrating 30yrs of publication, 1987-2017

Leukemia covers all aspects of the research and treatment of leukemia and allied diseases. Studies of normal hemopoiesis are covered because of their comparative relevance. Topics of interest are studies on oncogenes, growth factors, stem cells, leukemia genomics, cell cycle, signal transduction, molecular targets for therapy and more.

Impact Factor: 11.702*

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Volume 31, No 8
August 2017

ISSN: 0887-6924
EISSN: 1476-5551

2016 Impact Factor 11.702*
3/70 Hematology
11/217 Oncology

Robert Peter Gale, USA
Andreas Hochhaus, Germany

*2016 Journal Citation Reports® Science Edition (Clarivate Analytics, 2017)

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CAR-T cells represent a new and promising approach to cancer therapy, however, heterogeneity of cell products used in different clinical trials makes it difficult to interpret the basis for therapeutic success or failure. This study shows that CAR-T-cell products generated from defined T-cell subsets can provide uniform potency compared with products derived from unselected T cells that vary in phenotypic composition. These findings have important implications for the formulation of T-cell products for adoptive therapies.

Long-term benefits and risks of frontline nilotinib vs imatinib for chronic myeloid leukemia in chronic phase: 5-year update of the randomized ENESTnd trial
To enable a comprehensive evaluation of the long-term benefits and risks of nilotinib and imatinib for the treatment of patients with newly diagnosed CML-CP, this study provides updated results from ENESTnd based on a minimum follow-up of five calendar years, representing the full follow-up duration designated in the original study protocol.

Differential clinical effects of different mutation subtypes in CALR-mutant myeloproliferative neoplasms
A quarter of patients with essential thrombocythemia (ET) or primary myelofibrosis carry a driver mutation of CALR, the calreticulin gene. This study shows differential clinical effects of mutation subtypes - Type 2-like CALR mutations are mainly associated with an ET phenotype, low risk of thrombosis and indolent clinical course, while type 1-like mutations are mainly associated with a myelofibrosis phenotype and a high risk of progression from ET to myelofibrosis.

European LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemia
Most reports on CML treatment with tyrosine kinase inhibitors (TKIs) focus on efficacy, particularly on molecular response and outcome. In contrast, adverse events are often reported as infrequent, minor, tolerable and manageable, but they are increasingly important as therapy is potentially lifelong and multiple TKIs are available. For this reason, the European LeukemiaNet panel for CML management recommendations presents this critical summary of adverse events emerging during CML treatment, to assist their understanding, management and prevention.



Celebrating 30 years of publication - 1987-2017

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