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The cover shows a three-dimensional model of MDM2 splicing isoform MDM2-C in complex with Nutlin-3A. The protein is represented by its van der Waals surface, whereas Nutlin-3A is shown as colored sticks (C, grey; O, red; N, blue; Cl, green). For more information, see the paper by Bozzi et al on page 1232, this issue.