Laboratory Investigation - Figure 2 for article: Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH

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Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH

Marwa Mahmoud, Gillian M Borthwick, Alison A Hislop and Helen M Arthur

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Acvrl1 is expressed in the distal veins, distal arteries and capillaries of the pulmonary vasculature. Acvrl1 is not expressed in major pulmonary arteries and veins (a, b), but is present in distal arteries and distal veins (c–e). Inset in (b) shows magnified view. The transition point between non-expressing and Acvrl1-expressing arterial endothelium (arrow, c) is at a similar point to that for endoglin expression. Acvrl1 is strongly expressed in the capillaries (f). For abbreviations see legend of Figure 1. Scale bars: 100 m.

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FIGURE 2

Endoglin and activin receptor-like-kinase 1 are co-expressed in the distal vessels of the lung: implications for two familial vascular dysplasias, HHT and PAH

Figure 2.