Laboratory Investigation

FIGURE 2

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Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist

Takuya Ishibe, Akihiko Kimura, Yuko Ishida, Tatsunori Takayasu, Takahito Hayashi, Koichi Tsuneyama, Kouji Matsushima, Ikuhiro Sakata, Naofumi Mukaida and Toshikazu Kondo

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Figure 2.

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RT–PCR analysis for gene expression of CYP1A2, CYP2E1, and CYP3A11 in the livers of WT and IL-1ra KO mice before or after APAP treatment (200 mg/kg). Representative results from six independent experiments are shown in (a). The ratios of CYP1A2 (b), CYP2E1 (c), and CYP3A11 (d) to beta-actin in the livers of WT and IL-1ra KO mice are shown here. Each value represents meanplusminuss.e.m. (n=6 animals). * P<0.05, WT vs IL-1ra KO mice.

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