FIGURE 3
FROM:
MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model
Kyoichi Fukuda, Greg H Tesch, Felicia Y Yap, Josephine M Forbes, Richard A Flavell, Roger J Davis and David J Nikolic-Paterson
BACK TO ARTICLEFigure 3.
Islet cell apoptosis in MLD-STZ. Immunostaining for cleaved caspase-3 in pancreas tissue sections. (a) Normal WT mouse pancreas with no staining. (b) Day 14 of MLD-STZ in WT mice showing several apoptotic cells with nuclear staining for cleaved caspase-3 (arrows). (c) Fewer apoptotic cells (arrows) are seen in islets of Mkk3-/- mice on day 14 of MLD-STZ. (d) Quantification of apoptotic cells based upon immunostaining for cleaved caspase-3 in normal mice (n=3), on day 5 (n=4–5), or on day 14 (n=8–10) after STZ administration in WT (open bars) and Mkk3-/- (closed bars) mice. * P<0.05 vs WT by ANOVA with Newman–Keuls multiple comparison post-test.
