TABLE 1
FROM:
Off the beaten pathway: the complex cross talk between Notch and NF-
B
Clodia Osipo, Todd E Golde, Barbara A Osborne and Lucio A Miele
BACK TO ARTICLETable 1. Evidence of Notch-NF-B cross talk
| Model | Effect | Mechanism | Reference |
|---|---|---|---|
| Jurkat T-ALL cells | Notch-1 induces p100/p52 expression | Transcriptional, CSL mediated | 49 |
| Mouse hematopoietic precursors | Notch-1 induces p50, p65, RelB and c-Rel | Transcriptional, CSL mediated | 16 |
| Stellate liver cells | Notch-1 induces I B
| Transcriptional, CSL mediated | 50 |
| B cells | NF-B induces Jagged-1 | Transcriptional, canonical NF-B | 51 |
| Marginal zone B cells | NF-B induces HES-5 and Deltex-1 | Transcriptional, canonical NF-B | 52 |
| Jurkat T-ALL cells | Notch-1 inhibits NF-B (dose-dependent) | Physical interaction between p50 and Notch-1IC | 53,54 |
| Murine T cells | Notch-1 stimulates NF-B | Physical interaction between p50/c-Rel and Notch-1IC | 56 |
| Human primary keratinocytes | Notch ligand peptide stimulates NF-B | Unknown, short-term (IKK activation?) | 18 |
| Murine erythroleukemia cells | Cell-associated Jagged-2 stimulates NF-B | Unknown, short-term (IKK activation?) | 57 |
| Murine T-ALL (Notch-3IC transgenic) | Notch-3IC stimulates canonical NF-B | IKK signalosome dependent | 58 |
| Murine T-ALL (Notch-3IC transgenic) | Notch-3IC stimulates alternative NF-B2 | Physical interaction between Notch-3IC and IKK homodimers | 59 |
| Murine T-ALL (Notch-1IC transgenic) | Notch-1IC stimulates canonical NF-B | Physical interaction between Notch-1IC and IKK signalosome. Also, CSL-dependent effects | 61 |
| CEM T-ALL cells | Notch-1IC stimulates canonical NF-B | Physical interaction between Notch-1IC and IKK signalosome | 61 |
