Laboratory Investigation - Table 1 for article: Quantitative analysis of estrogen receptor heterogeneity in breast cancer

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Laboratory Investigation

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Quantitative analysis of estrogen receptor heterogeneity in breast cancer

Gina G Chung, Maciej P Zerkowski, Sriparna Ghosh, Robert L Camp and David L Rimm

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Table 1. Slide-to-slide ER heterogeneity

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Case	Block	Pathologist (%)	Mean AQUA^a	Standard error	P value; Block comparisons	P value; ANOVA
A	1	0	3.667	0.074	0.2446; 1 vs 2	0.1995
	2		3.461	0.152

B	1	10	3.332	0.072	<0.0001; 1 vs 2	<0.0001
	2		2.911	0.039	<0.0001; 2 vs 3
	3		2.51	0.048	<0.0001; 1 vs 3

C	1	20	51.803	1.105	<0.0001; 1 vs 2	<0.0001
	2		25.884	0.976	<0.0001; 1 vs 3
	3		21.433	0.733	<0.0001; 1 vs 4
	4		40.12	1.444	0.0077; 2 vs 3
					<0.0001; 2 vs 4
					<0.0001; 3 vs 4

D	1	20	100	2.55	<0.0001; 1 vs 2	<0.0001
	2		40.978	3.71

G	1	80	6.356	0.228	<0.0001; 1 vs 2^b	<0.0001
	2		10.063	0.289	0.0018; 1 vs 3
	3		5.527	0.138	<0.0001; 1 vs 4
	4		8.105	0.225	<0.0001; 1 vs 5
	5		4.979	0.167	<0.0001; 2 vs 3^b
					<0.0001; 2 vs 4^b
					<0.0001; 2 vs 5^b
					<0.0001; 3 vs 4
					0.1023; 3 vs 5
					<0.0001; 4 vs 5

H	1	90	63.836	3.31	<0.0001; 1 vs 3	<0.0001
	2		57.639	1.935	0.0811; 1 vs 2
	3		45.614	2.466	0.0007; 2 vs 3

I	1	95	20.845	1.027	0.2047; 1 vs 2	0.2047
	2		18.306	1.756

J	1	100	10.151	1.162	0.0042; 1 vs 2^b	0.0253
	2		7.035	0.366	0.0117; 1 vs 3^b
	3		6.93	0.285	0.69; 1 vs 4
	4		10.614	0.797	0.9348; 2 vs 3
					0.0025; 2 vs 4^b
					0.0067; 3 vs 4

K	1	100	36.778	2.056	<0.0001; 1 vs 2	<0.0001
	2		69.955	4.36

^a Normalized score to tissue controls and to maximum score (case D1).

^b Discordant block to block comparisons with AQUA binary values.

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