Laboratory Investigation

FIGURE 3

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Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries

Marc Beaussier, Dominique Wendum, Eduardo Schiffer, Sylvie Dumont, Colette Rey, André Lienhart and Chantal Housset

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Figure 3.

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Progression rates of ductular reaction and fibrosis in ischemia-induced liver injury. Liver tissue sections from rats with Sham operation (control), or with arterial liver ischemia at different time points after surgery, that isw day 2 (D2); weeks 1, 2, 6 (W1, 2, 6), were submitted to CK19 immunolabeling or to Sirius red staining, as shown in Figure 2. The CK19-labeled (open squares) and Sirius red-stained (closed squares) areas were measured using a computerized image analysis system and expressed as a percentage of total analyzed area. Results are meansplusminuss.d. from 10 consecutive fields; # P<0.05 vs previous value.

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