FIGURE 2

Association between ductular reaction and fibrosis development in ischemia-induced liver injury. Liver tissue sections from rats with arterial liver ischemia, on post-operative day 2 (a, b), weeks 1 (c, d), week 2 (e, f) and week 6 (g, h), were submitted to CK19 immunolabeling or to Sirius red staining. Portal tract-centered photomicrographs show the emergence of a ductular reaction at the portal tract periphery on week 1 (c, arrowheads), with periportal lobular extensions thereafter (e, g, arrows) and concomitant periductal/ductular accumulation of fibrosis (d, f, h). Results are representative of four animals at each time point; original magnification 100.