FIGURE 8

Phosphorylation of ERK and its inhibition by DX-9065a. Time course of phosphorylated p44/42 MAP kinase in the glomerular lysates of disease control and DX-9065a-treated groups is shown in (a) and (b), respectively. Levels of phosphorylated of p44/42 MAP kinase on day 8 are shown in (c). By densitometric analysis, phospholylation of p44/42 MAP kinase began on day 1 and continued through day 8, while they are suppressed by DX-9065a treatment (d). Normal group, gray column; disease control group, open column; and DX-9065a-treated group, closed column. ^* P<0.05, ^** P<0.01 vs disease control (six rates per group).