TABLE OF CONTENTS

Volume 87, Issue 11 (November 2007)

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Inside Lab Invest

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Pathobiology in Focus

Role of telomeres and telomerase in genomic instability, senescence and cancer FREE

Yibin Deng and Sandy Chang

87: 1071-1076; advance online publication, September 3, 2007; doi:10.1038/labinvest.3700673

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Mini Review

Pathobiology of transforming growth factor beta in cancer, fibrosis and immunologic disease, and therapeutic considerations FREE

Gérald J Prud'homme

87: 1077-1091; advance online publication, August 27, 2007; doi:10.1038/labinvest.3700669

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Research Articles

An orthotopic xenograft model of intraneural NF1 MPNST suggests a potential association between steroid hormones and tumor cell proliferation FREE

George Q Perrin, Hua Li, Lauren Fishbein, Susanne A Thomson, Min S Hwang, Mark T Scarborough, Anthony T Yachnis, Margaret R Wallace, Thomas H Mareci and David Muir

87: 1092-1102; advance online publication, September 17, 2007; doi:10.1038/labinvest.3700675

A refined method for molecular typing reveals that co-occurrence of PrPSc types in Creutzfeldt–Jakob disease is not the rule FREE

Silvio Notari, Sabina Capellari, Jan Langeveld, Armin Giese, Rosaria Strammiello, Pierluigi Gambetti, Hans A Kretzschmar and Piero Parchi

87: 1103-1112; advance online publication, September 24, 2007; doi:10.1038/labinvest.3700676

Comprehensive identification of proteins in Hodgkin lymphoma-derived Reed–Sternberg cells by LC-MS/MS FREE

Jeremy C Wallentine, Ki Kwon Kim, Charles E Seiler III, Cecily P Vaughn, David K Crockett, Sheryl R Tripp, Kojo S J Elenitoba-Johnson and Megan S Lim

87: 1113-1124; advance online publication, September 17, 2007; doi:10.1038/labinvest.3700672

Type IV collagen degradation in the myocardial basement membrane after unloading of the failing heart by a left ventricular assist device FREE

Annette H Bruggink, Matthijs F M van Oosterhout, Nicolaas de Jonge, Jack P M Cleutjens, Dick F van Wichen, Joyce van Kuik, Marcel G J Tilanus, Frits H J Gmelig-Meyling, Jan G van den Tweel and Roel A de Weger

87: 1125-1137; advance online publication, September 17, 2007; doi:10.1038/labinvest.3700670

Lack of hepatocellular CD10 along bile canaliculi is physiologic in early childhood and persistent in Alagille syndrome FREE

Jane A Byrne, Natalie J Meara, Anne C Rayner, Richard J Thompson and A S Knisely

87: 1138-1148; advance online publication, September 17, 2007; doi:10.1038/labinvest.3700677

ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging FREE

Ramana Vishnubhotla, Shan Sun, Jameela Huq, Marinka Bulic, Anil Ramesh, Grace Guzman, Michael Cho and Sarah C Glover

87: 1149-1158; advance online publication, September 17, 2007; doi:10.1038/labinvest.3700674

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Technical Report

Endothelial cells of human colorectal cancer and healthy colon reveal phenotypic differences in culture FREE

Vera Simone Schellerer, Roland Siegfried Croner, Kristina Weinländer, Werner Hohenberger, Michael Stürzl and Elisabeth Naschberger

87: 1159-1170; advance online publication, September 17, 2007; doi:10.1038/labinvest.3700671

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