Laboratory Investigation

FIGURE 2

FROM:

An orthotopic xenograft model of intraneural NF1 MPNST suggests a potential association between steroid hormones and tumor cell proliferation

George Q Perrin, Hua Li, Lauren Fishbein, Susanne A Thomson, Min S Hwang, Mark T Scarborough, Anthony T Yachnis, Margaret R Wallace, Thomas H Mareci and David Muir

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Figure 2.

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sNF96.2 cells have a Schwann-like phenotype. sNF96.2 cultures (a, c) were examined for the immunoexpression of two SC markers, S-100 (a) and p75 (c) by fluorescent immunocytochemistry. p75 was easily detected on the surface of sNF96.2 cells, while only faint cytoplasmic labeling for S-100 was observed. Distinct immunoexpression of these SC markers by sNF96.2 xenograft tumors was observed by immunoperoxidase methods (n, normal nerve; t, xenograft tumor) (Figure 2b and d, respectively). Original magnifications: (a, c): times 400; (b, d): times 200.

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