Laboratory Investigation

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ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging

Ramana Vishnubhotla, Shan Sun, Jameela Huq, Marinka Bulic, Anil Ramesh, Grace Guzman, Michael Cho and Sarah C Glover

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Figure 1.

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ROCK-I and -II are expressed in non-malignant and malignant intestinal cell lines. All five cell lines express ROCK-I, but HCT-116 cells have significantly lower ROCK-I expression than the other four cell lines. All five cell lines express ROCK-II. The least amount of fragmentation of ROCK-II was seen in HCT-116 cells in which two bands were visualized at 160 and 130 kDa respectively. B-actin was used as a loading control. This experiment was repeated in triplicate.

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