Laboratory Investigation

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Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton–Valentine leukocidin

Susan Boyle-Vavra and Robert S Daum

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Figure 1.

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Model for emergence of PVL producing CA-MRSA: a methicillin-susceptible S. aureus (MSSA) strain is infected and lysogenized by a phage (phiSLT) that harbors the lukS-PV and lukF-PV genes (pvl) encoding the PVL. Subsequently, a methicillin resistance cassette (SCCmec IV, V or V T) carrying the mecA gene is horizontally transferred into the pvl-positive MSSA strain and integrates into the genome in a location that is distinct from that of the phiSLT integration site.

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