Laboratory Investigation

FIGURE 4

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Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcoma

Jun Nishio, Pamela A Althof, Jacqueline M Bailey, Ming Zhou, James R Neff, Frederic G Barr, David M Parham, Lisa Teot, Stephen J Qualman and Julia A Bridge

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Figure 4.

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FISH and G-banding analyses of Case 34 (solid variant ARMS). (a) FISH analysis with the PAX3 (orange) and FKHR (green) spanning probes reveals PAX3-FKHR fusion signals (arrows), indicating the presence of a t(2;13) translocation. (b) Representative karyotype showing the following abnormal complement: 46,XY,del(6)(p21p25). Arrows indicate the involved breakpoints on the normal chromosome 6 homologue on the left. Cytogenetic studies did not reveal the characteristic translocation involving chromosomes 2 and 13.

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