Laboratory Investigation

FIGURE 2

FROM:

Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcoma

Jun Nishio, Pamela A Althof, Jacqueline M Bailey, Ming Zhou, James R Neff, Frederic G Barr, David M Parham, Lisa Teot, Stephen J Qualman and Julia A Bridge

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Figure 2.

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FISH analyses performed on cytologic touch preparations of Case 3 (ARMS). (a) FISH analysis with the FKHR breakpoint flanking probe set (proximal portion, orange; distal portion, green) shows splitting of the orange and green signals, indicating disruption of FKHR. (b) FISH analysis with the PAX3 breakpoint flanking probe set (proximal portion, orange; distal portion, green) shows splitting of the orange and green signals, indicating disruption of PAX3. (c) FISH analysis with the PAX3 (orange) and FKHR (green) spanning probes shows juxtaposed green and orange or overlapping yellow-white signals (arrows), confirming the presence of a PAX3-FKHR fusion.

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