Laboratory Investigation

FIGURE 1

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Inhibition of transforming growth factor bold italic beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice

Yoshikuni Nagashio, Hikaru Ueno, Michio Imamura, Hiroshi Asaumi, Shiro Watanabe, Taizo Yamaguchi, Masashi Taguchi, Mitsuo Tashiro and Makoto Otsuki

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Figure 1.

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Histological changes in the pancreas after repetitive cerulein injections. Pancreatic tissues of mice treated with cerulein (b and d) or saline as control (a and c) for 3 weeks were stained with Azan (a and b) or subjected to immunostaining for alpha-SMA (c and d). In control pancreas, collagen was seen around the pancreatic ducts and blood vessels (a). Repetitive cerulein treatment for 3 weeks caused intralobular and interlobular fibrosis with inflammatory infiltration and acinar cell atrophy (b). Only a few alpha-SMA-positive cells were present around the blood vessels in control pancreas (c), whereas an increased number of alpha-SMA-positive pancreatic stellate cells (PSCs) were observed in fibrotic area in cerulein-treated mice (d), Original magnification, times 200.

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