TABLE 2
FROM:
Immunopolarization of CD4+ and CD8+ T Cells to Type-1–Like is Associated with Melanocyte Loss in Human Vitiligo
Anna Wa
kowicz-Kaliska, René M J G J van den Wijngaard, Bert J Tigges, Wiete Westerhof, Graham S Ogg, Vincenzo Cerundolo, Walter J Storkus and Pranab K Das
Table 2. Distribution of T Cells in Non-Involved and Perilesional Skin, T Cell Lines and Clones of Five Vitiligo Patients
| NL skin biopsy | PL skin biopsy | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % CD4+ | % CD8+ | % CD4+ | % CD8+ | |||||||||||
| Patient | Distribution of T cells | in situ | TCL | TCC | in situ | TCL | TCC | Distribution of T cells | in situ | TCL | TCC | in situ | TCL | TCC |
| 1 | Dermis | 60 | 79 | 100 (17) | 40 | 21 | 0 (0) | Dermis, dermoepidermal junctiona | 23 | 25 | 21 (8) | 77 | 75 | 79 (34) |
| 2 | Dermis, dermoepidermal junctiona | 43 | 48 | 100 (48) | 57 | 52 | 0 (0) | Dermis, dermoepidermal junctiona | 35 | 21 | 73 (32) | 65 | 79 | 27 (12) |
| 3 | Dermis, dermoepidermal junctiona | 44 | 40 | 50 (14) | 56 | 60 | 50 (13) | Dermis, dermoepidermal junctiona | 23 | 29 | 13 (2) | 77 | 71 | 87 (13) |
| 4 | Dermis | 65 | 89 | nd (0) | 35 | 11 | nd (0) | Dermis, dermoepidermal junctiona | 52 | 5 | 2 (1) | 48 | 95 | 98 (55) |
| 5 | Dermis, dermoepidermal junctiona | 16 | 8 | 0 (8) | 84 | 92 | 78 (30) | Dermis | 28 | 30 | 50 (19) | 72 | 70 | 50 (19) |
Number of clones generated from each biopsy is indicated in parentheses.
a Hallmark: Clusters of T cells are located in juxtaposition to microscopic appearance of degenerating melanocytes.
NL, nonlesional; PL, perilesional; TCL, T-cell lines; TCC, T-cell clones.
