FIGURE 5
FROM:
CCR3-Blocking Antibody Inhibits Allergen-Induced Eosinophil Recruitment in Human Skin Xenografts from Allergic Patients
Stéphanie Sénéchal, Olivier Fahy, Thibaut Gentina, Han Vorng, Monique Capron, Andrew F Walls, Alan R McEuen, Mark G Buckley, Qutayba Hamid, Benoît Wallaert, André Bernard Tonnel and Anne Tsicopoulos
BACK TO ARTICLEFigure 5.
Infiltration of CD4+ T cells, CD45RO+ memory T cells, mMBP+ eosinophils, BB1+ basophils and cytokine mRNA+ cells after allergen versus diluent challenges in 28 skin grafts obtained from allergic donors (each donor is represented by a different symbol), 24 hours after ip introduction of IgG2a- or anti-CCR3-treated autologous human PBMC. Results are expressed as number of positive cells per field. Median values are represented by the solid bars. Differences within the four groups were first evaluated by using the Kruskal-Wallis test and were found statistically significant for CD4, BB1, mMBP, IL-4, and IL-5 mRNA but not for CD45RO, IFN-
, and IL-2 mRNA. When significant, comparisons within allergen and diluent values were performed by using the Wilcoxon test. Comparisons between IgG2a and anti-CCR3-treated groups were performed by using the Mann-Whitney U test after subtraction of the diluent values from the allergen values. p values are indicated and were considered significant when less than 0.05.
