Laboratory Investigation - Figure 4 for article: Inhibitors of Phosphodiesterase Isoforms III or IV Suppress Islet-Cell Nitric Oxide Production

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Inhibitors of Phosphodiesterase Isoforms III or IV Suppress Islet-Cell Nitric Oxide Production

Evette Beshay and Gérald J Prud'homme

Figure 4.

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Agents that increase intracellular cyclic-3',5' adenosine monophosphate (cAMP) levels suppress NO production. The results represent the percent of inhibition of nitrite production by NIT-1 insulinoma cells stimulated as described in the legend to Figure 1. A, cAMP analogs, dibutyryl cAMP (solid line) or 8-bromo-cAMP (broken line). B, Adenylate cyclase stimulator (forskolin). Data represent percent inhibition of nitrite production plusminus 1 sd of triplicate cultures in a representative experiment, and three experiments yielded similar results (Panels A and B).

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FIGURE 4

Inhibitors of Phosphodiesterase Isoforms III or IV Suppress Islet-Cell Nitric Oxide Production

Figure 4.