Laboratory Investigation

FIGURE 2

FROM:

Analysis of the Lung Pathology and Alveolar Macrophage Function in the Acid Sphingomyelinase–Deficient Mouse Model of Niemann-Pick Disease

Rajwinder Dhami, Xingxuan He, Ronald E Gordon and Edward H Schuchman

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Figure 2.

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Total cell numbers in the bronchoalveolar lavage fluid (BALF) of ASMKO mice. There is no change in the total number of cells in the BALF of normal mice with increasing age. (+/-) mice have significantly higher cell numbers compared with normal mice at 22 to 26 weeks of age, whereas in (-/-) mice the total number of cells in the BALF is significantly increased at 10 and at 22 to 26 weeks of age compared with normal mice. Values are shown as mean plusminus standard deviation, n = 5 to 6 mice per group. White bars, 4 weeks; striped bars, 10 weeks; hatched bars, 22 to 26 weeks.

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