FIGURE 1
FROM:
Analysis of the Lung Pathology and Alveolar Macrophage Function in the Acid Sphingomyelinase–Deficient Mouse Model of Niemann-Pick Disease
Rajwinder Dhami, Xingxuan He, Ronald E Gordon and Edward H Schuchman
BACK TO ARTICLEFigure 1.
Light micrographs of normal (A and B) and acid sphingomyelinase knock-out (ASMKO) (C and D) formalin-fixed lungs from approximately 24-week-old mice after bronchoalveolar lavage (BAL). At low magnification (
20) many foamy cells can be seen in the airspaces of the ASMKO lungs (C) and large numbers of inflammatory cells are visible in the lung microvasculature, but otherwise histology is similar to that in normal mouse lungs (A). At higher magnification ( 100) foamy cells are also seen in the pulmonary interstitium (arrows), as well as in the airspaces (arrowhead) of ASMKO mice (D), and the alveolar walls appear thickened compared with normal mouse lungs (B). Sections were stained with hematoxylin and eosin.
