Laboratory Investigation

TABLE 4

FROM:

Increased Expression of FGF-8 Isoforms and FGF Receptors in Human Premalignant Prostatic Intraepithelial Neoplasia Lesions and Prostate Cancer

Eeva M Valve, Marja T Nevalainen, Martti J Nurmi, Matti K Laato, Paula M Martikainen and Pirkko L Härkönen

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Table 4. Summary of the Results of Immunohistochemical Stainings for FGF-8 and FGFR1 and FGFR2 in Prostate Cancer

Prostate cancerGrade (WHO)Gleason gradeFGF-8FGFR1FGFR2
P9I3 + 20/++++N/A
 PIN ++/++++++N/A
P31I2 + 30/+++N/A
 PIN ++++N/A
P69I2 + 40/++N/AN/A
 PIN ++N/AN/A
P54II3 + 5+/++++N/A
P65II3 + 4+N/AN/A
P68II3 + 3+++N/AN/A
P70II4 + 3++/++++++
P88II3 + 3++++
 PIN +/+++++
P90II3 + 30/+++++/++++/++
 PIN 0/++++/++++/++
 Normal 0/+00
P91II3 + 4++0/+++0/++
 PIN +/++0/+++0/++
 Normal 0/+00
P92II3 + 40/++/+++0/++
 PIN +/+++0/++
 Normal 0/+00
P8III4 + 4+++++
P46III3 + 5++++/+++++

 N/A, not analyzed.

 Intensity of immunoreactivity: 0, none; +, weak; ++, moderate; +++, strong; 0/+, 0/++, 0/+++, +/++, +/+++, ++/+++: heterogenous distribution of immunoreactivity.

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