FIGURE 2
FROM:
Caspase-3 Activity as a Prognostic Factor in Colorectal Carcinoma
Liesbeth E Jonges, J Fred Nagelkerke, N Geeske Ensink, Edo A van der Velde, Rob A E M Tollenaar, Gert Jan Fleuren, Cornelis J H van de Velde, Hans Morreau and Peter J K Kuppen
BACK TO ARTICLEFigure 2.
Immunohistochemical detection of apoptotic tumor cells. Apoptotic tumor cells were immunohistochemically detected with M30, a cleavage product of keratin 18 and a marker for apoptotic epithelial cell death. An example of M30 staining of a low caspase-3 active tumor (87 pmol AMC/minute/mg tumor) (A) and a high caspase-3 active tumor (2021 pmol AMC/minute/mg tumor) (B) are shown. Tumor (t) and stroma (s) are indicated. The stromal part is distinguished from tumor cells by laminin expression (blue). Examples of M30+ tumor cells (brown) present in the high caspase-3 active tumor are indicated with arrows.
