Laboratory Investigation

FIGURE 1

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Amyloid and Nonfibrillar Deposits in Mice Transgenic for Wild-Type Human Transthyretin: A Possible Model for Senile Systemic Amyloidosis

Mei-hui Teng, Jian-yun Yin, Ruben Vidal, Jorge Ghiso, Asok Kumar, Rahmin Rabenou, Alan Shah, Daniel R Jacobson, Clement Tagoe, Gloria Gallo and Joel Buxbaum

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Figure 1.

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The human transthyretin (TTR) gene was cloned as a 19.2 kb NheI fragment, containing all the sequences known to be required for tissue specific expression, in Charon 40 grown in either Escherichia coli ED 8767 or K 802. The leuright arrowpro substitution at amino acid 55 is encoded by a Tright arrowC transversion in the second position in the codon, located in exon 3.

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