FIGURE 6
FROM:
Potential Role of the Chemokine Receptors CXCR3, CCR4, and the Integrin 
E
7 in the Pathogenesis of Psoriasis Vulgaris
James B Rottman, Tammy L Smith, Kenneth G Ganley, Toyoko Kikuchi and James G Krueger
BACK TO ARTICLEFigure 6.
Expression of various adhesion molecules in psoriatic lesions and nonlesional skin. There was abundant vascular cell adhesion molecule-1 (VCAM-1) expression by dermal endothelium and a subset of perivascular MNCs in psoriatic lesions (A) and patchy expression by endothelium within nonlesional skin (B). The VCAM-1 ligand VLA-4 was expressed by a significant number of perivascular MNCs within psoriatic lesions (C), and rare VLA-4 immunoreactive cells were present within nonlesional skin (D). E-cadherin was constitutively expressed in both psoriatic lesions and nonlesional skin, principally at the level of intracellular junctions within the epidermis (E and F). The adhesion molecule 
E
7 was expressed specifically by intra-epidermal lymphocytes and rare dermal cells within lesional skin (G). In contrast, few E7 immunoreactive cells were present within nonlesional skin (H). (Immunoperoxidase technique; hematoxylin counterstain; magnification, 
400).
