Laboratory Investigation

FIGURE 5

FROM:

Localization of Tissue Transglutaminase in Human Carotid and Coronary Artery Atherosclerosis: Implications for Plaque Stability and Progression

Zishan A Haroon, Thomas Wannenburg, Madhu Gupta, Charles S Greenberg, Reidar Wallin and David C Sane

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Figure 5.

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Transglutaminase is detected in intimal and adventitial microvessels of an atherosclerotic coronary artery. TG antigen was often detected in microvessels, as demonstrated in these photomicrographs. A, Presence of TG antigen in intimal microvascular endothelial cells (as well as some other cells) is shown. B, Immunoreactivity for von Willebrand factor to identify the endothelial cells in a section adjacent to that shown in A. C and D, The medial-adventitial border. The external elastic lamina is identified by the black arrowheads. TG antigen (C) is present in the microvascular endothelium and in the SMC that are present in the medium (upper right-hand corner). Endothelial cells were identified using an antibody to von Willebrand factor (D). Original magnification, times 400.

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