Laboratory Investigation

FIGURE 1

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Cytomegalovirus Infection of the Central Nervous System Stem Cells from Mouse Embryo: A Model for Developmental Brain Disorders Induced by Cytomegalovirus

Isao Kosugi, Yuichiro Shinmura, Hideya Kawasaki, Yoshifumi Arai, Ren-Yong Li, Satoshi Baba and Yoshihiro Tsutsui

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Figure 1.

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Phase contrast micrographs of uninfected (A to C) and murine cytomegalovirus (MCMV)-infected (D and E) epidermal growth factor-responsive central nervous system (CNS) stem cells, and immunofluorescence for MCMV immediate early (IE) antigen (F). A, A single CNS stem cell just after passage. B, Small aggregates of the stem cells 1 day after passage. C, A symmetrical sphere 5 days after passage. D, CNS stem cells infected with MCMV at multiplicity of infection (MOI) 1, shown at 1 day post-infection (dpi). E, MCMV-infected CNS stem cells showing cytopathic effect on 5 dpi. F, MCMV-infected CNS stem cells expressing the IE antigen at 3 dpi. Bar = 20 mum.

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